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CompletedNCT02572362Updated Dec 13, 2016

Secondary Cancer Risk After Radiation Therapy for Rectal Cancer

An observational study in Neoplasms, Second Primary, sponsored by Kantonsspital Graubuenden. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2016-12-13.

Sponsored by Kantonsspital Graubuenden · Observational

Study type
Observational
Time perspective
Retrospective
Enrollment
25
Ages
18 Years to 100 Years
Sex
All
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Study summary

Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.

Read the detailed description

A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.

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Conditions studied

  • Neoplasms, Second Primary
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In context

Neoplasms, Second Primary

247 studies on the registry are indexed under Neoplasms, Second Primary; 48 are open to participants now.

This study's enrollment of 25 is below the median of 290 across 60 observational studies indexed under Neoplasms, Second Primary.

Browse Neoplasms, Second Primary studies →

Lead sponsor

Kantonsspital Graubuenden is the lead sponsor of 6 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients having had radiation therapy for rectal cancer. Estimation of second cancer risk using data from planning CTs comparing dose Distribution using different Radiation therapy techniques (3DCRT vs VMAT).

Inclusion criteria

  • Male/Female > 18 years of age
  • pre or postoperative radiation therapy for rectal cancer
  • Planning CT

Exclusion criteria

Exclusion Criteria:

  • Planning CT not available
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Study design

Time perspective
Retrospective
Enrollment
25 participants (actual)
Patient registry
No

Interventions

  • OtherNo intervention in this retrospective study

    No Intervention in this retrospective Analysis. All patients included did receive Radiation therapy Independent of this study

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What researchers measure

Primary outcomes

  1. Calculation of the organ-specific excess lifetime attributable risk (LAR) (%)

    LAR is calculated for variable Ages at exposure

    Time frame: 60 years (model-based calculation)

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Study locations

1 site
  • Klinik Hirslanden, Institute for Radiotherapy
    Zurich, CH-8032, Switzerland
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References and documents

Publications

  • Zwahlen DR, Bischoff LI, Gruber G, Sumila M, Schneider U. Estimation of second cancer risk after radiotherapy for rectal cancer: comparison of 3D conformal radiotherapy and volumetric modulated arc therapy using different high dose fractionation schemes. Radiat Oncol. 2016 Nov 10;11(1):149. doi: 10.1186/s13014-016-0723-6. PubMed 27832799 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 13, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02572362
Lead sponsor
Kantonsspital Graubuenden
Collaborators
Klinik Hirslanden, Zurich
Responsible party
Daniel Rudolf Zwahlen (MD, MBA, Kantonsspital Graubuenden) — Principal investigator
First posted
Oct 8, 2015
Start date
Aug 2015
Primary completion
Nov 2016
Completion
Nov 2016
Last update
Dec 13, 2016

Study contacts

Daniel R Zwahlen, MD, MBA
principal investigator · Kantonsspital Graubuenden

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2016. You cannot join it, but the record below documents what was studied.

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