An interventional study of Glucose and Inulin in Obesity, sponsored by University of Toronto. Completed. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-09-29.
Sponsored by University of Toronto · Not applicable, Interventional, and Basic science
The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes. The investigators aimed to compare the effects of two fermentable fibers (inulin and resistant-starch) on postprandial SCFA, glucose, insulin, free-fatty acids (FFA) and gut hormone responses and to compare the responses in healthy overweight and obese (OWO) vs lean (LN) participants. Methods: Using a randomized, single blind, crossover design, 13 OWO and 12 LN overnight fasted participants were studied on 3 separate occasions. On each day they consumed a 300 mL drink containing 75g glucose (Control) or 75g glucose plus 24g inulin (IN), or 28.2g resistant-starch (RS). A standard lunch was served 4 h after the test drink.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 25 is below the median of 78 across 4,878 interventional studies indexed under Obesity.
Browse Obesity studies →University of Toronto is the lead sponsor of 397 studies on the registry; 59 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants with body mass index \<=25
Other: Glucose · Other: Inulin · Other: Resistant Starch
Participants with body mass index \>25
Other: Glucose · Other: Inulin · Other: Resistant Starch
75g glucose
75g glucose plus 24g inulin
75g glucose plus 28.2g resistant starch
Incremental area under the serum acetate response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the serum propionate response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the serum butyrate response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the breath hydrogen response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the breath methane response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the serum glucose response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum glucose response curve
Time frame: For 2 hours after consuming the standard lunch
Incremental area under the serum insulin response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum insulin response curve
Time frame: For 2 hours after consuming the standard lunch
Incremental area under the serum c-peptide response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum c-peptide response curve
Time frame: For 2 hours after consuming the standard lunch
Total area under the serum free-fatty acid response curve
Time frame: For 4 hours after consuming the test meal
Total area under the serum free-fatty acid response curve
Time frame: For 2 hours after consuming the standard lunch
Incremental area under the serum glucagon-like peptide-1 response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum glucagon-like peptide-1 response curve
Time frame: For 2 hours after consuming the standard lunch
Incremental area under the serum peptide-YY response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum peptide-YY response curve
Time frame: For 2 hours after consuming the standard lunch
Incremental area under the serum ghrelin response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum ghrelin response curve
Time frame: For 2 hours after consuming the standard lunch
No study locations are listed for this record.
This study is completed, as verified in Sep 2015. You cannot join it, but the record below documents what was studied.
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University of Toronto