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SuspendedNCT02533778ARISEUpdated Aug 2, 2017

ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization

An interventional study of mechanical thrombectomy in Ischemic Stroke, sponsored by Abington Memorial Hospital. Suspended at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-08-02.

Sponsored by Abington Memorial Hospital · Not applicable, Interventional, and Treatment

Why this study was suspended
Similar large international competing trial with results of strong positive statistically benefit
Phase
Not applicable
Study type
Interventional
Enrollment
25
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

A prospective pilot study to evaluate the recanalization and safety of mechanical thrombectomy through a cerebral angiogram in patients with stroke symptoms last seen normal between 8 - 24 hours.

Read the detailed description

Ischemic stroke patients who are 8-24 hrs from symptom onset without prior mechanical or IV thrombolytic treatment and are screen with CT or MR perfusion imaging showing penumbra and infarction not > 1/3rd the territory.

02

Conditions studied

03

In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's planned enrollment of 25 is below the median of 50 across 5,369 interventional studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Abington Memorial Hospital is the lead sponsor of 9 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Over 18 years last seen normal between 8 - 24 hours, without prior history of intravenous plasminogen activator (IV t-PA ) or
  • mechanical thrombectomy Vessels - intracranial vertebral artery, basilar artery, intracranial ICA, ICA terminus bifurcation, MCA M1/M2, or
  • ACA NIHSS ≥ 7 MRI DWI/PWI or
  • CTA/P, which demonstrates an area of mismatch ≥ 2/3 rd
  • Signed informed consent

Exclusion criteria

Exclusion Criteria:

  • creat >= 2
  • NIHSS \< 7
  • Baseline mRS >= 2
  • infarct > 1/3rd MCA territory
  • competing trials
  • prior IV or IA treatment
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
25 participants (estimated)

Study arms

  • Experimental
    Interventional mechanical thrombectomy

    Mechanical thrombectomy with either Penumbra system, TREVO, or Solitaire device for acute stroke symptom onset between 8 - 24 hours

    Device: mechanical thrombectomy

Interventions

  • Devicemechanical thrombectomy

    Mechanical thrombectomy by either Penumbra system, TREVO, or Solitaire retrieval device

    Also known as: Penumbra system, TREVO, Solitaire

06

What researchers measure

Primary outcomes

  1. Thrombolysis in Cerebral Infarction (TICI) score

    Time frame: 6 months

Secondary outcomes

  1. National Institutes of Health Stroke Scale (NIHSS) score

    Time frame: 6 months

  2. Montreal Cognitive Assessment (MoCA) tool

    Time frame: 6 months

  3. Modified Rankin Scale

    Time frame: 6 months

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Study locations

1 site
  • Abington Memorial Hospital
    Abington, Pennsylvania 19001, United States
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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 2, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02533778
Lead sponsor
Abington Memorial Hospital
Responsible party
Patricia Bussinger (MBA CRNP, Abington Memorial Hospital) — Principal investigator
First posted
Aug 27, 2015
Start date
Jul 2015
Primary completion
Jul 1, 2018 (estimated)
Completion
Jul 1, 2018 (estimated)
Last update
Aug 2, 2017

Study contacts

Qaisar Shah, MD
principal investigator · Abington Memorial Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is suspended, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.

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