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CompletedNCT02532920Updated Sep 22, 2016

The Natural History of Atopic Disease in Thai Children and Association With Atopic March

An observational study in Atopic Dermatitis, sponsored by Mahidol University. Completed at 1 site in Thailand. Open to participants aged Up to 15 Years. Per ClinicalTrials.gov, last updated 2016-09-22.

Sponsored by Mahidol University · Observational

Study type
Observational
Model
Ecologic or community
Time perspective
Retrospective
Enrollment
102
Ages
Up to 15 Years
Sex
All
01

Study summary

Atopic dermatitis(AD) is one of manifestation in atopic march. The prevalence of AD is increased. In 1998, the investigators found the prevalence of AD about 15 % in Thailand. AD is diagnosed by clinical as Hanifin and Rajka criteria. There are 3 group of severity defined by SCORAD(Scoring Atopic Dermatitis) : mild (\<25), moderate (25-50) and severe (>50). The natural history of AD was mentioned in 3 groups: complete remission, persistent and intermittent. Atopic march is the progression of atopic disease that has atopic dermatitis as the first manifestation then patients will have allergic rhinitis or asthma in the future. The investigators do a retrospective study to understand the natural history of AD as well as it associate with atopic march. That might be a predictive factor of AD and atopic march

Read the detailed description

Retrospective review from out patient record. Collect the demographic data, onset of atopic march, sensitization of allergen and treatment that given to patients.

For patients who have current follow up at Allergy clinic, the current symptom was collect in that visit.

For patients who didn't have follow up visit, telephone interview was done. If they have symptom, investigators will ask them to come in for investigation and proper treatment.

Patient was recruited in this study with parental permission. The data will collect and use statistical analysis.

02

Conditions studied

  • Atopic Dermatitis

Keywords

  • Natural history
  • Atopic dermatitis
  • Atopic march
03

In context

Dermatitis, Atopic

1,419 studies on the registry are indexed under Dermatitis, Atopic; 258 are open to participants now.

This study's enrollment of 102 is below the median of 150 across 237 observational studies indexed under Dermatitis, Atopic.

Browse Dermatitis, Atopic studies →

Lead sponsor

Mahidol University is the lead sponsor of 731 studies on the registry; 116 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Up to 15 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patient who was diagnosed with atopic dermatitis by physician by searching ICD 10(L20.9, L20.8)

Inclusion criteria

  • Diagnosis of AD by physician at birth-15 years old
  • Diagnosed by physician by Hanifin and Rajka criteria: itching, dry skin, chronic dermatitis : at face, extensor area (infant), flexor area (children and adult), with or with out history of atopy in family
  • Follow at allergy clinic once a year or can ask current symptom via telephone interview.
  • Evaluate severity of the disease by SCORAD (Scoring Atopic Dermatitis )

Exclusion criteria

Exclusion Criteria:

  • Onset of atopic dermatitis more than 15 years old.
  • Other disease: skin, cardiovascular, liver disease, endocrine, neurology, ect
  • Not complete data collection in case record form in out patient record.
  • Cannot be reach current symptom of patient.
05

Study design

Observational model
Ecologic or community
Time perspective
Retrospective
Enrollment
102 participants (actual)
Patient registry
No

Groups and cohorts

  • Atopic dermatitis

    Atopic dermatitis is diagnosis as Hanifin and Rajka from physician.

06

What researchers measure

Primary outcomes

  1. To evaluate the natural history of atopic dermatitis in Thai children and the factors that could be associate with the progression of the disease.

    complete remission (no AD rash and no topical steroid (TS) or topical tacrolimus (TT) use more than one year), persistent (use TS/TT once a month to control AD) and intermittent (other than two groups)

    Time frame: Recruited the AD patient who was diagnosed between at birth until 15 years old. The following time at allergy clinic about 4 years in average.

Secondary outcomes

  1. The association of atopic dermatitis and atopic march.

    Time frame: At the first diagnosis of atopic dermatitis until current Allergic visit or telephone interview.The following time at allergy clinic about 4 years in average.

07

Study locations

1 site
  • Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University
    Bangkok, 10700, Thailand
08

References and documents

Publications

  • Nicol NH, Boguniewicz M, Strand M, Klinnert MD. Wet wrap therapy in children with moderate to severe atopic dermatitis in a multidisciplinary treatment program. J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):400-6. doi: 10.1016/j.jaip.2014.04.009. PubMed 25017527 ↗
  • Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI; ISAAC Phase Three Study Group. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol. 2009 Dec;124(6):1251-8.e23. doi: 10.1016/j.jaci.2009.10.009. PubMed 20004783 ↗
  • Chung Y, Kwon JH, Kim J, Han Y, Lee SI, Ahn K. Retrospective analysis of the natural history of atopic dermatitis occurring in the first year of life in Korean children. J Korean Med Sci. 2012 Jul;27(7):723-8. doi: 10.3346/jkms.2012.27.7.723. Epub 2012 Jun 29. PubMed 22787365 ↗
  • Vichyanond P, Jirapongsananuruk O, Visitsuntorn N, Tuchinda M. Prevalence of asthma, rhinitis and eczema in children from the Bangkok area using the ISAAC (International Study for Asthma and Allergy in Children) questionnaires. J Med Assoc Thai. 1998 Mar;81(3):175-84. PubMed 9623008 ↗
  • Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology. 1993;186(1):23-31. doi: 10.1159/000247298. PubMed 8435513 ↗
  • Shaker M. New insights into the allergic march. Curr Opin Pediatr. 2014 Aug;26(4):516-20. doi: 10.1097/MOP.0000000000000120. PubMed 24886953 ↗
  • Illi S, von Mutius E, Lau S, Nickel R, Gruber C, Niggemann B, Wahn U; Multicenter Allergy Study Group. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004 May;113(5):925-31. doi: 10.1016/j.jaci.2004.01.778. PubMed 15131576 ↗
  • Wisniewski JA, Agrawal R, Minnicozzi S, Xin W, Patrie J, Heymann PW, Workman L, Platts-Mills TA, Song TW, Moloney M, Woodfolk JA. Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis. Clin Exp Allergy. 2013 Oct;43(10):1160-70. doi: 10.1111/cea.12169. PubMed 24074334 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 22, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02532920
Lead sponsor
Mahidol University
Responsible party
Orathai Piboonpocanun (Division of Allergy and Immunology, Department of Pediatrics, Siriraj hospital, Mahidol University) — Principal investigator
First posted
Aug 26, 2015
Start date
Jan 2015
Primary completion
Jun 2016
Completion
Jun 2016
Last update
Sep 22, 2016

Study contacts

Orathia Piboonpocanun, professor
study director · Siriraj Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2016. You cannot join it, but the record below documents what was studied.

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