An interventional study of Propofol and Sevoflurane in Microcirculatory Effects of Anesthesia and Inhalation and Intravenous Anesthesia, sponsored by National Taiwan University Hospital. Status unknown at 1 site in Taiwan. Open to female participants aged 20 Years to 65 Years. Per ClinicalTrials.gov, last updated 2016-04-13.
Sponsored by National Taiwan University Hospital · Not applicable and Interventional
Effects of different general anesthetics on peripheral microcirculation.
Human keep body temperature in a narrow range by a variety of regulatory mechanism. Peripheral thermal receptors send signals to central nervous system which regulate body temperature via peripheral effectors, such as vasoconstriction, vasodilatation, shivering, sweating and etc. In patients undergoing general anesthesia, the regulatory mechanism is altered. General anesthesia changes blood distribution in the body, the metabolic rate of muscle, threshold of thermal regulation in the brain and etc, so that heat distribution and microcirculation condition will also change. In this study, near-infrared spectroscopy (NIRS) is used to measure the microcirculatory condition. NIRS is a non-invasive continuous measurement to detect tissue saturation with the method of different wavelength of near-infrared. General anesthesia with inhalational sevoflurane and intravenous propofol is separated into 2 groups. Because of different mechanism of general anesthesia of these 2 anesthetics, different physiologic response may occur. Body temperature and somatic saturation are compared in each group.
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This study's planned enrollment of 100 is above the median of 42 across 881 interventional studies indexed under Respiratory Aspiration.
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Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
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Exclusion Criteria:
Anesthesia maintained with inhalational sevoflurane
Drug: Sevoflurane · Procedure: General anesthesia induction
Anesthesia maintained with intravenous propofol continuous infusion
Drug: Propofol · Procedure: General anesthesia induction
General anesthesia maintained with intravenous propofol infusion
General anesthesia maintained with inhalational sevoflurane
Induce routine of general anesthesia, including propofol 1-3mg/kg, fentanyl 1-3mcg/kg, cisatracurium 0.2-0.3mg/kg.
Somatic saturation
Change of somatic saturation measured by NIRS
Time frame: during surgery, approximately 2-4 hr
Body temperature
Nasal and peripheral temperature
Time frame: during surgery, approximately 2-4 hr
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National Taiwan University Hospital