An observational study in Quality of Life, Syndromes and Aging, sponsored by Helsinki University Central Hospital. Active, not recruiting. Open to male participants aged 31 Years to 46 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-08-18.
Sponsored by Helsinki University Central Hospital · Observational
The Helsinki Businessmen Study (HBS) is a clinico-epidemiological longitudinal study started in 1964. It also included a 5-year randomized, controlled multifactorial primary prevention trial of cardiovascular diseases between 1974-1980. The cohort is being actively followed-up through national registers since the 1980, and since 2000 with regular questionnaire surveys. Latest in 2015. Also clinical and laboratory studies have been performed in random subcohorts. Follow-up is ongoing with new hypothesis-generating research questions.
The Helsinki Businessmen Study (HBS) was originally a convenient cohort of male executives and businessmen (born 1919-1934, n=3490), who participated in health check-ups between 1964-1973, but since the beginning of 1970s it has developed into a clinico-epidemiological longitudinal study. Primary focus was on the prevention of cardiovascular diseases (CVD), but since 2000 focus has been shifting to geriatrics, and with its long follow-up (up to 50 years) HBS can be seen as a "life-course" study. Traditional CVD risk factors are available from the 1960s and in 1974 participants (available n=3310) were divided in groups according to their clinical status and CVD risk. Two high-risk groups (n=1222) and low-risk group (n=593) participated in a 5-year multifactorial primary prevention study in 1974-1980 (in-trial and post-trial results have been published in 1985 and 1991). The whole original cohort has been followed-up from national registers since 1985 and with regular questionnaire surveys since 2000. Random subcohorts have been studied clinically with laboratory and genetic examinations in 2003 and 2011. The latest questionnaire survey was performed in winter 2015 by which two thirds of the original cohort had died. Follow-up of the cohort is ongoing and new research questions formulated..
4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.
This study's enrollment of 3,490 is above the median of 573 across 1,485 observational studies indexed under Cardiovascular Diseases.
Browse Cardiovascular Diseases studies →Helsinki University Central Hospital is the lead sponsor of 299 studies on the registry; 60 are open to participants now.
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Originally a convenient cohort of male executives and businessmen (born 1919-1934, n=3490), who participated in health check-ups during 1964-1973, but since the beginning of 1970s it has developed into a clinic-epidemiological longitudinal study.
Exclusion Criteria:
Various cardiovascular risk groups described below
Healthy but at high risk in 1974
Other: Intervention
Healthy but at high risk in 1974
Healthy and at low risk in 1974
Medications or clinical disease in 1974
Refused or no response in 1974
Multifactorial intervention with lifestyle changes and drugs as needed
Total mortality: national registers
Time frame: change from baseline up to 612 months
Health-related quality of life: questionnaire data
Time frame: change from baseline up to 612 months
Geriatric syndromes and disability: questionnaires, clinical examinations, registers
Time frame: change from baseline up to 612 months
Morbidity: self-report, national registers, hospital and autopsy records
Time frame: change from baseline up to 612 months
Medications: self-report, national registers
Time frame: change from baseline up to 612 months
Cause-specific mortality: national registers, autopsy records
Time frame: change from baseline up to 612 months
No study locations are listed for this record.
This study is active, not recruiting, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.
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Helsinki University Central Hospital