An interventional study of Exercise in Healthy, sponsored by University of Nottingham. Status unknown at 1 site in United Kingdom. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-12-09.
Sponsored by University of Nottingham · Not applicable, Interventional, and Prevention
Maintaining muscle mass and function is important in healthy ageing to maintain quality of life. Loss of muscle mass is major problem, as beyond the age \~50, muscle mass declines by \~1-2% a year. To prevent this loss, the investigators need to understand the mechanism regulating muscle mass as we age. In this project the investigators aim to determine these mechanisms using a new technique of heavy water ingestion, this allows measurement of multiple aspects of skeletal muscle mass metabolism e.g. protein synthesis, over long periods (6 weeks) as people go about their normal everyday activities. The investigators also aim to determine the influence of resistance exercise training on older muscle, as well as differences between men and women in muscle responses to exercise and nutrition HMB (beta-hydroxy-beta-methylbutyrate).
University of Nottingham is the lead sponsor of 455 studies on the registry; 77 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Young Individuals (18-30y) studied before and after 6 weeks unilateral resistance exercise training
Behavioral: Exercise
Old individuals (65-75y) studied before and after 6 weeks of unilateral resistance exercise training
Behavioral: Exercise
Old individuals (65-75y) studied before and after 6 weeks of unilateral resistance exercise training with HMB (beta-hydroxy-beta-methylbutyrate) supplementation
Behavioral: Exercise
Old individuals (65-75y) studied before and after 6 weeks of unilateral resistance exercise training with Omega 3 supplementation
Behavioral: Exercise
Muscle Protein Synthesis
Comparison of muscle protein synthesis between young and older individuals and in response to 6 weeks unilateral exercise training and supplementation
Time frame: 0-6 Weeks
Muscle Strength
Maximal voluntary contractions of the quadriceps will be performed (leg extension) in the trained and untrained legs. This will be performed at baseline and repeated throughout to monitor training progression
Time frame: 0-6 Weeks
This study is status unknown, as verified in Dec 2015. You cannot join it, but the record below documents what was studied.
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University of Nottingham