An interventional study of Neuropsychological tests and A cranial MRI in Alzheimer's Disease, sponsored by Rennes University Hospital. Completed at 1 site in France. Open to participants aged 25 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-05-24.
Sponsored by Rennes University Hospital · Not applicable, Interventional, and Other
Unrandomized, unblinded, monocentric comparative Functional Magnetic Resonance Imaging study.
Prospective functional Magnetic Resonance Imaging study involving a group of participants with Mild Cognitive Impairment due to AD and a control participants group matched for age, education level, verbal Intelligence Quotient as assessed through the French version of the National Adult Reading Test and income group following National Institute of Statistics and Economics Studies classification.
3,681 studies on the registry are indexed under Alzheimer Disease; 875 are open to participants now.
This study's enrollment of 100 is above the median of 70 across 2,809 interventional studies indexed under Alzheimer Disease.
Browse Alzheimer Disease studies →Rennes University Hospital is the lead sponsor of 440 studies on the registry; 51 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Volunteers (pilot phase)
Volunteers (experimental phase)
AD-MCI participants
Exclusion Criteria:
MRI contraindications (all participants)
Wearing of any metal implant such as:
Other criteria (all participants)
Other criteria (control participants)
Other criteria (AD-MCI participants)
60 old healthy volunteers (aged 25-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: * Neuropsychological tests * Experimental procedure
Other: Neuropsychological tests · Other: Experimental procedure
20 patients (aged 60-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: * Neuropsychological tests * Experimental procedure * A cranial MRI
Other: Neuropsychological tests · Device: A cranial MRI · Other: Experimental procedure
20 healthy volunteers (aged 60-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: * Neuropsychological tests * Experimental procedure * A cranial MRI
Other: Neuropsychological tests · Device: A cranial MRI · Other: Experimental procedure
Scales and tests to evaluate: * Global cognitive performance * Handedness * Memory functions performance * Gestural praxis functions performance * Lexical and semantic functions performance * Executive functions performance * Memory disorders * Way of life * Mood
Improvement of recognition memory accuracy measures under the familiarity condition as compared with the novel condition in the AD-MCI group
Time frame: 3 months
Significant effect of the familiarity vs novelty condition on the pattern of % BOLD signal change in across the brain in the AD-MCI group
Time frame: 3 months
Significant group effect on the pattern of % BOLD signal change in across the brain
Time frame: 3 months
Predictive validity of the brain % BOLD signal change pattern for participants clinical status (i.e. controls vs. AD-MCI)
Time frame: 3 months
Significant interaction between the kind of familiarity condition (i.e. novel, experimental or pre-experimental) and the estimates of recognition memory processes efficiency (i.e. respective contributions of recollection and familiarity, % correct)
Time frame: 3 months
This study is completed, as verified in May 2023. You cannot join it, but the record below documents what was studied.
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Rennes University Hospital