An interventional study of shorter or longer period of specific dietary restrictions in Egg Hypersensitivity, sponsored by Dominque Bullens. Status unknown at 6 sites in Belgium. Open to participants aged 12 Months to 18 Years. Per ClinicalTrials.gov, last updated 2021-11-05.
Sponsored by Dominque Bullens · Not applicable, Interventional, and Other
Step 1: open baked egg test passed (either at home or in the hospital): this is routine clinical practice; afterwards daily intake of increasing amounts of heated egg (amounts to be noted in diary)
Step 2: open provocation test at home with hard-boiled egg, both hen's egg white and yolk, passed; afterwards weekly intake of either hard-boiled egg white or yolk or both (amounts and days to be noted in diary)
Step 3: open provocation test at home with waffles, omelet, pan cake or scrambled egg passed; afterwards weekly or two-weekly intake of one of these specific preparation forms or of the previous preparation forms (amounts, days and preparation to be noted in diary)
Step 4: open provocation test at home with fried or poached egg or softly boiled egg with liquid yolk; afterwards regular intake of one of these preparation forms or one of the prior steps (amounts, days and preparation to be noted in diary)
Step 5: open provocation test at home with raw egg: eg. In chocolate mousse; mayonnaise or tiramisu; afterwards unlimited intake of all egg containing preparation forms (for 3 months in both groups to be noted in the diary)
If tolerance to a certain step is not yet present (this is: if any reaction occurred during the months registered between two steps), the next step will be postponed. The number of failures (any reaction in relation to egg ingestion), the type of reaction and the additional time period necessary before the next step can be taken, will be recorded. After each time period, the investigators will measure specific IgE to hen's egg white and to Gal d 1, as standard clinical practice.
38 studies on the registry are indexed under Egg Hypersensitivity; 9 are open to participants now.
This study's enrollment of 86 is above the median of 73 across 27 interventional studies indexed under Egg Hypersensitivity.
Browse Egg Hypersensitivity studies →Dominque Bullens is the lead sponsor of 2 studies on the registry; none are open to participants now.
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Exclusion Criteria:
arm 18m: 6 months between step 1 and step 2; 6 months between step 2 and step 3, 3 months between all other steps step by step gradual introduction of egg containing food products during 18 months, unless next step can not be taken
Behavioral: shorter or longer period of specific dietary restrictions
arm 30m: 9 months between step 1 and step 2; 9 months between step 2 and step 3, 6 months between all other steps step by step gradual introduction of egg containing food products during 30 months, unless next step can not be taken
Behavioral: shorter or longer period of specific dietary restrictions
step by step gradual introduction of egg containing food products
time to complete egg tolerance
raw egg tolerance (eg in chocolate mousse)
Time frame: 18 to 30 months
Measurement of specific IgE to egg white components to predict complete egg tolerance
Time frame: 18 to 30 months
Plan to share: No — data will be analysed and grouped before release
No publications or documents are linked to this record.
This study is status unknown, as verified in Nov 2021. You cannot join it, but the record below documents what was studied.
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Dominque Bullens