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CompletedNCT02479269AEBNPCRPUpdated May 10, 2016

The Influence of Aerobic Exercise on Serum Brain Natriuretic Peptide and C- Reactive Protein in Cardiovascular Disease

An interventional study of Aerobic exercise in Cardiovascular Disease, sponsored by Shiraz University of Medical Sciences. Completed. Open to participants aged 40 Years to 65 Years. Per ClinicalTrials.gov, last updated 2016-05-10.

Sponsored by Shiraz University of Medical Sciences · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
40 Years to 65 Years
Sex
All
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Study summary

The purpose of this study was to investigate the effects of 8 weeks of aerobic exercise on serum concentrations of Brain Natriuretic Peptide and C - reactive protein in patients with cardiovascular disease. Patients were divided randomly into two groups: control and experimental aerobic group. This study was done with two - stage blood sampling: at the beginning and at the end of the treatment phase. All subjects were requested to avoid any exercise at least 48 hours before blood sampling. To study Brain Natriuretic Peptide and C - reactive protein changes, 5 milliliters of blood were taken from patient's brachial vein. Blood samples for subsequent measurements were frozen immediately and transported to the Hormone Laboratory for serum separation. The experimental group did the aerobic exercise programs for 8 weeks for 3 sessions per week and the control group did not receive any training. After completion of training, the final blood samplings were performed. Exercise intensity according to the heart rate remained stable until the last week. Brain Natriuretic Peptide and C - reactive protein levels were measured by ELISA tests. All statistical analysis were done using SPSS software (version 16) and at the significance level of p≤ 0.05

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Conditions studied

  • Cardiovascular Disease

Keywords

  • Brain Natriuretic Peptide
  • aerobic execise
  • C- Reactive Protein
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In context

Cardiovascular Diseases

4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.

This study's enrollment of 60 is below the median of 100 across 2,738 interventional studies indexed under Cardiovascular Diseases.

Browse Cardiovascular Diseases studies →

Lead sponsor

Shiraz University of Medical Sciences is the lead sponsor of 129 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
40 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • In this trial patients with coronary artery disease more than 70 percent at least in one coronary vessel with Ejection Fraction more than 40 percent in recent Echo cardiograph without acute evidence of ischemia or congestive heart failure symptoms were selected and are divide randomly into two groups.

Exclusion criteria

Exclusion Criteria:

  • Patients with acute evidence of ischemia or congestive heart failure symptoms are excluded.
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Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    intervention

    Aerobic exercise+ blood sampling

    Other: Aerobic exercise

  • No intervention
    control

    Blood sampling

Interventions

  • OtherAerobic exercise

    Aerobic exercise for 8 weeks

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What researchers measure

Primary outcomes

  1. Brain Natriuretic Peptide

    Time frame: 8 weeks

  2. serum C - reactive protein

    Time frame: 8 weeks

Secondary outcomes

  1. serum lipoproteins

    Time frame: 8 weeks

  2. Body Mass Index

    Time frame: 8 weeks

  3. blood pressure

    Time frame: 8 weeks

07

Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 10, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02479269
Lead sponsor
Shiraz University of Medical Sciences
Collaborators
Islamic Azad University, Shiraz
Responsible party
Najmeh Sheykhiyan (Master, Islamic Azad University, Shiraz) — Principal investigator
First posted
Jun 24, 2015
Start date
Mar 2015
Primary completion
May 2015
Completion
May 2015
Last update
May 10, 2016

Study contacts

Dr Mohammad Ali Ostovan, Cardiologist
study director · Shiraz University of Medical Sciences

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2016. You cannot join it, but the record below documents what was studied.

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