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CompletedNCT02473484GLIOMICUpdated Dec 22, 2017

Search of Protein Biomarkers in Order to Achieve a Molecular Classification of Gliomas

An observational study in Glioblastoma, sponsored by University Hospital, Lille. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-12-22.

Sponsored by University Hospital, Lille · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
78
Ages
18 Years and older
Sex
All
01

Study summary

The aim is to classify high grade glioma by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI). In order to provide more specific informations for the diagnosis and the prognosis of high grade glioma.

02

Conditions studied

  • Glioblastoma

Keywords

  • High Grade Glioma
  • Proteomics
  • MALDI-MSI
03

In context

Glioblastoma

1,920 studies on the registry are indexed under Glioblastoma; 450 are open to participants now.

This study's enrollment of 78 is above the median of 60 across 188 observational studies indexed under Glioblastoma.

Browse Glioblastoma studies →

Lead sponsor

University Hospital, Lille is the lead sponsor of 625 studies on the registry; 141 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

high grade glioma

Eligibility criteria

Main inclusion criteria:

  • Patients with grade III or IV glioma newly diagnosed with histological evidence
  • Surgical indication
  • Tumor tissue available at biobank of Lille
  • Men and women aged ≥ 18 years
  • Informed Consent signed by the patient or his legal representative.

Main exclusion criteria:

  • Antecedents of other cancers except basal cell skin cancer or carcinoma in situ of the uterus cervix
  • Previous history of brain radiotherapy
  • Anti-tumor systemic treatments (chemotherapy or targeted therapy) prior to surgery of glioma
  • Genetic disease that may cause brain tumor, potentially radiation-induced tumor
  • History of degenerative neurological disease prior to diagnosis
  • contraindication to MRI
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
78 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna
06

What researchers measure

Primary outcomes

  1. To evaluate the correlation between the WHO classification 2007 only established standard diagnostic and classification by mass spectrometry gliomas (lipids, peptides, proteins)

    Time frame: 2.5 years

07

Study locations

1 site
  • Le Rhun
    Lille, 59000, France
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 22, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02473484
Lead sponsor
University Hospital, Lille
Responsible party
Sponsor
First posted
Jun 16, 2015
Start date
Jun 24, 2014
Primary completion
Oct 2017
Completion
Oct 2017
Last update
Dec 22, 2017

Study contacts

Emilie Le RHUN, MD
principal investigator · University Hospital, Lille

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2017. You cannot join it, but the record below documents what was studied.

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