A Study of Apatinib Tablets in the Treatment of Advanced or Metastatic Gastric Cancer

1. Age: 18 to75 years old;
2. Pathologically diagnosed with advanced gastric cancer (including adenocarcinoma of the gastroesophageal junction);
3. Failure of prior therapy (during or after treatment) in patients who have received at least two prior chemotherapy regimens;
4. ECOG PS of 0-2;

5. Major organ function has to meet the following criteria:

   For results of blood routine test (without blood transfusion within 14 days):

   HB ≥ 90g / L ANC ≥ 1.5 × 109 / L PLT ≥ 80 × 109 / L

   Biochemical tests results:

   Bilirubin \<1.25 times the upper limit of normal (ULN) ALT and AST \<2.5 × ULN; liver metastases, if any, the ALT and AST\<5 × ULN Serum Cr ≤ 1 × ULN endogenous creatinine clearance>50ml/min (Cockcroft-Gault formula)

6. An expected survival of ≥ 3 months;
7. Patient received apatinib treatment regimen at investigators' discretion;
8. Patient has to voluntarily join the study and sign the Informed Consent Form for the study;
9. Pregnancy test (serum or urine) has to be performed for woman of childbearing age within 7 days before enrolment and the test result must be negative. They shall take appropriate methods for contraception during the study until the 8th week post the last administration of study drug. For men, (previous surgical sterilization accepted), shall agree to take appropriate methods of contraception during the study until the 8th week post the last administration of study drug.

Exclusion Criteria:

1. Subjects with uncontrolled arterial hypertension (systolic blood pressure> 140 mmHg and diastolic blood pressure > 90 mm Hg) despite standard medical management; Grade ≥ 2 coronary heart disease; Grade ≥ 2 arrhythmia (including QT interval prolongation, for man > 450 ms, for woman > 470 ms), as well as Grade ≥ 2 cardiac dysfunction;
2. Factors that could have an effect on oral medication (such as inability to swallow, chronic diarrhea and intestinal obstruction);
3. Subjects with high gastrointestinal bleeding risk, including the following conditions: presence of active ulceration combined with a positive fecal occult blood test (++);history of hematemesis and melena within three months before enrollment; unresected primary lesion in stomach with positive fecal occult blood test (+), ulcerated gastric carcinoma with massive alimentary tract bleeding risk judged by PIs based on gastric endoscopy finding;
4. Abnormal coagulation (INR>1.5、APTT>1.5 UNL), with tendency of bleeding;
5. Presence of central nervous system metastases;
6. Pregnant or lactating women;
7. Other conditions regimented at investigators' discretion.