An observational study in Severe Malnutrition, Malnutrition and Infant Nutrition Disorders, sponsored by Institut Hospitalo-Universitaire Méditerranée Infection. Completed at 2 sites in 2 countries. Open to participants aged Up to 59 Months, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-04-10.
Sponsored by Institut Hospitalo-Universitaire Méditerranée Infection · Observational
The investigators performed two case-control studies in Niger and Senegal analysing fecal microbiota to characterize the specificity of the gut microbiota alteration associated with severe acute malnutrition (SAM).
Fecal samples of cases (severe acute malnutrition (SAM) ascertained according to the WHO definition) and controls (asymptomatic healthy children ascertained by clinical and anthropometric criteria) were analysed by v3v4 16S rRNA sequencing, redox and pH measurement and using specific polymerase chain reaction targeting Methanobrevibacter smithii and Bacteroides thetaiotaomicron. Based on the literature and oxydative stress reported in SAM, the investigators tested if the proportion of aerotolerant prokaryotes is increased among gut prokaryotes enriched in SAM in comparison to prokaryotes enriched in controls. The investigators further linked this to fecal redox potential and assessed the total number of bacteria in feces by flux cytometry.
1,277 studies on the registry are indexed under Malnutrition; 230 are open to participants now.
This study's enrollment of 100 is below the median of 206 across 393 observational studies indexed under Malnutrition.
Browse Malnutrition studies →Institut Hospitalo-Universitaire Méditerranée Infection is the lead sponsor of 3 studies on the registry; none are open to participants now.
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Children from Niamey and Dakar, Senegal
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Exclusion Criteria:
Stool samples on Children with and without severe acute malnutrition in Senegal recruited in 3 locations (Dakar, Dielmo and Ndiop)
Biological: Stool samples
Stool samples Children with and without severe acute malnutrition in Niger recruited in Niamey
Biological: Stool samples
Stool samples
Aerotolerant Odds ratio (AOR)
AOR = (number of aerotolerant prokaryotes enriched in the gut of children with SAM \* number of obligate anaerobic prokaryotes enriched in controls)/(number of aerotolerant prokaryotes enriched in controls \* number of obligate anaerobic prokaryotes enriched in children with SAM)
Time frame: 1 day (Participants were not followed as this is a case-contol study only clinical and anthropometric data and fecal samples were collected the day of inclusion)
The record gives a start of Jan 2014, a primary completion of Mar 2015 and a completion of Mar 2015. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Apr 2015. You cannot join it, but the record below documents what was studied.
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Institut Hospitalo-Universitaire Méditerranée Infection