An interventional study of Sucralose and Water in Obesity, sponsored by University of Illinois at Urbana-Champaign. Completed at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-09-21.
Sponsored by University of Illinois at Urbana-Champaign · Not applicable, Interventional, and Basic science
The purpose of this research study is to examine whether sugar-replacement sweeteners that are currently on the market (ex. Sucralose, which is in Splenda) change how well the body works to control blood sugar.
The investigators of this study have recently found that sucralose, the most commonly used non-nutritive sweetener (NNS), affects the glycemic response to an oral glucose tolerance test (OGTT) and potentiates glucose-stimulated insulin secretion in obese people who are not regular consumers of NNS. However, studies conducted in healthy lean adults, none of which control for previous use of NNS, show that sucralose does not affect glycemic or hormonal responses to the ingestion of glucose or other carbohydrates. Therefore, we do not know a) whether sucralose effects are limited to obese subjects, or are generalizable to lean people when controlling for prior history of NNS consumption, and b) mechanism(s) responsible for the acute effect of sucralose on glucose metabolism as we measured in obese subjects. The aim of this study is to determine the effects of an acute intake of sucralose on the metabolic response to an oral glucose tolerance test in lean and obese people.
University of Illinois at Urbana-Champaign is the lead sponsor of 188 studies on the registry; 29 are open to participants now.
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Exclusion Criteria:
Subjects will drink sucralose 10 min before drinking a glucose load
Dietary Supplement: Sucralose · Dietary Supplement: glucose load
Subjects will drink water 10 min before drinking a glucose load
Other: Water · Dietary Supplement: glucose load
Subjects will taste and spit up sucralose 10 min before drinking a glucose load
Dietary Supplement: Sucralose · Dietary Supplement: glucose load
60 ml of 2mM sucralose
60 ml of water
Peak insulin secretion rate
Blood samples will be collected before and for 5 hours after drinking a glucose load to determine plasma insulin and C-peptide. Insulin secretion rate will be assessed using the minimal model of Breda and collaborators.
Time frame: up to 5 hours after drinking a glucose load
Glucose rate of appearance
Blood samples will be collected before and for 5 hours after drinking a glucose load to determine glucose and glucose tracer:tracee ratios.
Time frame: up to 5 hours after drinking a glucose load
Glucose-dependent insulinotropic polypeptide (GIP)
Blood samples will be collected before and for 5 hours after drinking a glucose load to determine GIP.
Time frame: up to 5 hours after drinking a glucose load
Sucralose concentrations in plasma
Sucralose concentrations in plasma will be measured by using liquid chromatography-mass spectrometry.
Time frame: up to 310 min after drinking the sucralose load
This study is completed, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.
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University of Illinois at Urbana-Champaign