Clinical Effect of Platelet Rich Plasma Combined With Laser on Scar

Browse trials for

• Cicatrix 307

Keywords

• acne scar
• fractional carbon dioxide laser
• platelet rich plasma

Cicatrix

307 studies on the registry are indexed under Cicatrix; 50 are open to participants now.

This study's enrollment of 29 is below the median of 39 across 251 interventional studies indexed under Cicatrix.

Lead sponsor

Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.

Study arms

• Experimental
  fractional CO2 laser with PRP

  fractional carbon dioxide laser followed by intradermal injection of platelet rich plasma

  Procedure: fractional carbon dioxide laser with platelet rich plasma

• Active comparator
  fractional CO2 laser with NS

  fractional carbon dioxide laser followed by intradermal injection of NS

  Procedure: fractional carbon dioxide laser with NS

Interventions

• Procedurefractional carbon dioxide laser with platelet rich plasma

  fractional carbon dioxide laser followed by platelet rich plasma injection

  Also known as: COFRAX with autologous PRP

• Procedurefractional carbon dioxide laser with NS

  fractional carbon dioxide laser followed by normal saline injection

  Also known as: COFRAX with normal saline

Primary outcomes

1. Global assessment of acne scar

   5-point grading of acne scar

   Time frame: 12 weeks

Secondary outcomes

1. ECCA (échelle d'évaluation clinique des cicatrices d'acné)

   quantitative analysis of acne scar

   Time frame: 12 weeks

2. adverse effect assessment

   adverse effect assessment - erythema index, Epithelization Scale (0-12 point)

   Time frame: 12 weeks

Publications

• Tierney EP, Eisen RF, Hanke CW. Fractionated CO2 laser skin rejuvenation. Dermatol Ther. 2011 Jan-Feb;24(1):41-53. doi: 10.1111/j.1529-8019.2010.01377.x. PubMed 21276157 ↗