An observational study in Knee Injuries, sponsored by Chin-Hung Chang. Status unknown at 1 site in Taiwan. Per ClinicalTrials.gov, last updated 2015-03-02.
Sponsored by Chin-Hung Chang · Observational
According to many recent research, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis.
Based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of total knee replacement. The investigators are going to isolate and expand MSC from these two tissues respectively, and then compare the chondrogenesis ability for clinical application. In the other hand, the investigators plan to build techniques and procedures which comply with "Good Tissue Practices (GTP)"
249 studies on the registry are indexed under Knee Injuries; 48 are open to participants now.
This study's planned enrollment of 6 is below the median of 90 across 79 observational studies indexed under Knee Injuries.
Browse Knee Injuries studies →Chin-Hung Chang is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Patient who have an total knee replacement surgery
Patient who have an total knee replacement surgery
Exclusion Criteria:
Patient who don't sign the agreement
For patients who have an operation of total knee replacement, two removed tissues (synovial membrane and infrapatellar fat pad) will be collected for mesenchymal stem cell isolation.
Other: 103024-F
mesenchymal stem cell isolation
Cell viability ratio of synovial membrane MSC and infrapatellar fat pad MSC from the first to the tenth cell passage
Time frame: 6 months
Doubling time of synovial membrane MSC and infrapatellar fat pad MSC from the first to the tenth cell passage
Time frame: 6 months
Percentage expression of cluster differentiation 90,105, 34, 45 surface markers of synovial membrane MSC and infrapatellar fat pad MSC from the first to the tenth cell passage
Time frame: 6 months
Alcian blue staining of synovial membrane MSC and infrapatellar fat pad MSC
Time frame: 6 months
Tyep II collagen and aggrecan gene expression of synovial membrane MSC and infrapatellar fat pad MSC
Time frame: 6 months
This study is status unknown, as verified in Feb 2015. You cannot join it, but the record below documents what was studied.
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