An interventional study of Autologous blood and Bronchial plug in Pneumothorax, sponsored by Tang-Du Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2016-01-06.
Sponsored by Tang-Du Hospital · Not applicable, Interventional, and Treatment
The purpose of this study is to determine whether injecting autologous blood or putting bronchial plug through bronchoscope is effective in the treatment of refractory pneumothorax.
This is a multi-site, controlled, randomized study. Refractory pneumothorax is a challenge for respiratory physicians. Many patients present recurrent pneumothorax. Thoracic closed drainage is a basic and effective treatment to pneumothorax. Chronic obstructive pulmonary disease(COPD)is one of the main causes of spontaneous pneumothorax. Many patients precluded the performance of surgery for poor pulmonary function. In China, economical load is another reason for patients who are unwilling to surgery. So we want to seek a cheap, effective and safe method for refractory pneumothorax. We will adopt three methods in this study. Conventional thoracic closed drainage was continuously used in the control group, autologous blood was perfused to the target pulmonary segment in the treatment A group and self-made silicone bronchial plug was placed to the target pulmonary segment in the treatment B group. The leak position was detected by biliary lithotomy balloon. Main outcome measures: duration of continuous leakage. Secondary end-points included the lung reexpanded, hospital costs and hospital stays etc.
178 studies on the registry are indexed under Pneumothorax; 42 are open to participants now.
This study's planned enrollment of 269 is above the median of 100 across 115 interventional studies indexed under Pneumothorax.
Browse Pneumothorax studies →Tang-Du Hospital is the lead sponsor of 164 studies on the registry; 77 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Autologous blood was perfused to the target pulmonary segment
Other: Autologous blood
Bronchial plug was placed to the target pulmonary segment
Device: Bronchial plug
Control group was given to continuous negative pressure drainage
Autologous blood was perfused to the target pulmonary segment
Bronchial plug was placed to the target pulmonary segment
Duration of air leakage
Time frame: up to two weeks
duration of pulmonary atelectasis
Time frame: up to two weeks
Arterial blood gas
Time frame: participants will be followed for the duration of hospital stay, an expected average of 4 weeks
complications
Complications refers to the complications related to bronchoscopy treatment(include hemoptysis, short of breath, chest pain, fever )
Time frame: participants will be followed for the duration of hospital stay, an expected average of 4 weeks
hospital costs
Time frame: participants will be followed for the duration of hospital stay, an expected average of 4 weeks
Duration of hospital stays
Time frame: participants will be followed for the duration of hospital stay, an expected average of 4 weeks
This study is status unknown, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.
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Tang-Du Hospital