An observational study in Peritoneal Surface Malignancies, sponsored by Yonsei University. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-11-02.
Sponsored by Yonsei University · Observational
The most popular surgical treatment of peritoneal cancer is the type known as hyperthermic intraperitoneal chemoperfusion (HIPEC), a type of cytoreductive surgery for which a significantly high survival rate has been demonstrated by several studies. It is widely known that HIPEC entails severe physiological changes and precautions during anesthesia. However, very few studies have systematically outlined and organized these changes for each system, and most existing studies only report retrospective data or are limited to gynecological surgeries. Therefore, the present researchers planned a prospective observational study to determine the physiological changes that occur in patients during HIPEC cytoreductive surgeries performed in the colon and rectal surgery department of the investigators hospital. The investigators planned to monitor the patients' body temperature, metabolism, cardiovascular and respiratory changes during HIPEC cytoreductive surgery and analyze the anesthetic methods applied to identify the optimal anesthetic management strategy for HIPEC cytoreductive surgeries.
361 studies on the registry are indexed under Peritoneal Neoplasms; 56 are open to participants now.
This study's enrollment of 22 is below the median of 100 across 53 observational studies indexed under Peritoneal Neoplasms.
Browse Peritoneal Neoplasms studies →Yonsei University is the lead sponsor of 1,387 studies on the registry; 232 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients who undergoing HIPEC cytoreductive surgery
Exclusion Criteria:
Drug: HIPEC cytoreductive surgery
At least 30 minutes prior to the prospective conclusion of the surgery, 1 μg/kg of fentanyl is administered for postoperative analgesia and 0.075mg of palonosetron is IV-infused for the prevention of nausea and vomiting. Desflurane and remifentanil administration is ceased after the surgery is concluded, muscle relaxation is evaluated by train of four (TOP) monitoring using a nerve stimulator, and the neuromuscular blockade is reversed with 0.2 mg of glycopyrrolate and 1 mg of neostigmine. When the patient recovers consciousness and begins spontaneous respiration, extubation is performed and the patient is transferred to the ICU with monitoring of their vital signs.
Vital sign
Time frame: from 30 minutes to 90 minutes after HIPEC
Body temperature
Time frame: from 30 minutes to 90 minutes after HIPEC
serum glucose
Time frame: from 30 minutes to 90 minutes after HIPEC
pulmonary vascular permeability index
Time frame: from 30 minutes to 90 minutes after HIPEC
This study is completed, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.
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Yonsei University