An observational study in Neonatal Acute Kidney Injury and Childhood Chronic Kidney Disease, sponsored by Matthew Harer, MD. Status unknown at 1 site in United States. Open to participants aged 2 Years to 7 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-05-12.
Sponsored by Matthew Harer, MD · Observational
The purpose of this study is to learn more about how to identify signs of early chronic kidney diseases in children who were born prematurely with low birth weight (less than 3 ½ pounds). Researchers plan to compare the kidney function in children who experienced acute kidney injury (AKI) in the Neonatal Intensive Care Unit (NICU) with those who did not experience it. Evidence from several studies and our experience at UVA show that older children who experienced AKI while in the Pediatric Intensive Care Unit (PICU) have increased risk of developing early chronic kidney disease, and they also show early changes in the urine and blood that is consistent with early chronic kidney disease. In this study, the investigators hope to determine if any of these changes can be detected in early childhood, and if so, at what age we can start detecting these changes.
3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.
This study's planned enrollment of 80 is below the median of 192 across 1,033 observational studies indexed under Kidney Diseases.
Browse Kidney Diseases studies →This is the only study on the registry with Matthew Harer, MD as lead sponsor.
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Children born prematurely less than 1500 grams who stayed in the University of Virginia NICU.
Exclusion Criteria:
This group of babies born less than 1500 grams will have experienced acute kidney injury based on the modified KDIGO guidelines for acute kidney injury.
This group of babies born less than 1500 grams will have not experienced acute kidney injury in the NICU.
This group of babies born at term will have not experienced any acute kidney injury.
Composite Abnormality
Either eGFR \> 90, urine protein/creatinine \> 0.2, or BP \> 95th percentile for age and height
Time frame: Age 2-7 years
Growth
Evaluation of height, weight and BMI
Time frame: Age 2-6 years
Kidney Size
Evaluation of kidney size
Time frame: Age 2-6 years
Urinary Biomarkers
Evaluation of urine for biomarkers which can be used to detect early chronic kidney disease
Time frame: Age 2-6 years
This study is status unknown, as verified in May 2016. You cannot join it, but the record below documents what was studied.
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