An interventional study of Aerobic Exercise in Gut Microbiota, sponsored by Pennington Biomedical Research Center. Withdrawn. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-01-11.
Sponsored by Pennington Biomedical Research Center · Not applicable, Interventional, and Prevention
In the present study, we seek to elucidate the effects of aerobic exercise on fecal microbiota following the aforementioned no exercise control group and two doses of aerobic exercise training (the exercise training spans \~24 wks) in a cross-sectional sample.
We will collect ancillary data for the ongoing Examination of Mechanisms of exercise-induced weight compensation (E-Mechanic; RCT; Martin CK and Church TS Co-PI's; R01 HL 102166) to investigate the independent aim and hypothesis of this pilot and feasibility (P \& F) grant examining if there are differences in colonic microbial populations from a fecal sample following supervised and controlled aerobic exercise.
The proposed study seeks to better understand the role of colonic microbial populations as a mechanism of change in body weight during aerobic exercise. E-Mechanic is examining the effects of 2 tightly controlled and supervised doses of aerobic exercise, and a no-exercise control group, on energy balance and body weight over 24 wks in overweight and obese persons. The two aerobic exercise doses were: 1) 8 kcal/kg of body weight/week (KKW) (\~900 kcal/wk) and 2) 20 KKW (\~2250 kcal/wk) compared to a no exercise control group. The low dose of exercise (8 KKW) represents the American College of Sports Medicine (ACSM) recommendation for overall health and the higher dose (20 KKW) the recommendation for weight loss and weight loss maintenance.
Aim 1 To investigate if colonic bacterial populations differ between the exercise groups and the healthy living control group following aerobic exercise.
It is hypothesized that participants in the exercise group will have different bacterial populations than those in the healthy living control group.
Pennington Biomedical Research Center is the lead sponsor of 277 studies on the registry; 29 are open to participants now.
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Inclusion Criteria:
Participants are overweight or obese (BMI 25 ≥ kg/m2 and ≤ 45 kg/m2), not actively exercising > 20 min on ≥ 3 days/wk, weight stable, non-diabetic, non-smoker, and not have any major medical disorders including such as HIV, CVD, mental illness
Healthy Living Control Group
8 kcal/kg of body weight/week (KKW) (\~900 kcal/wk)
Behavioral: Aerobic Exercise
20 KKW (\~2250 kcal/wk)
Behavioral: Aerobic Exercise
The exercise expenditure goals were calculated by multiplying the participants' body weight by the exercise dose (8 or 20 KKW) divided by the number of sessions (3-5 sessions/wk). The speed and grade were monitored and documented to keep participant heart rate at 65-85% of tested VO2 peak and entered into ACSM equations for energy expenditure.
Gut Microbiota
Time frame: 1 year
No study locations are listed for this record.
This study is withdrawn, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.
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Pennington Biomedical Research Center