An interventional study of Reduced contrast DECT scan and Standard contrast SECT scan in Aortic Aneurysm, sponsored by University of Washington. Completed at 1 site in United States. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2018-05-14.
Sponsored by University of Washington · Not applicable, Interventional, and Diagnostic
The goal of this study is to validate that Dual Energy CT (DECT) urography when performed with a 50% reduction in iodinated contrast dose results in a CT exam with equal or better image quality and equal or better diagnostic capability compared to traditional Single Energy CT (SECT) performed with a standard contrast dose.
The investigators hypothesize that DECT urography performed with a 50% iodine dose reduction is equivalent to SECT urography performed with a full iodine dose for:
In addition, the investigators hypothesize that DECT virtual non-contrast images using material suppression from the same low iodine CT exam results in equivalent diagnostic information compared to SECT true non-contrast images obtained in the same patient during the same exam. If the true non-contrast images could be replaced by the virtual non-contrast images without loss of information, there is potential for DECT to both significantly lower radiation dose as well as significantly decreasing iodine dose.
The investigators designed this research protocol to prospectively test these hypotheses in a population scanned with a 50% reduced iodine DECT urography protocol compared to a control population scanned with a standard iodine dose clinical SECT urography protocol.
663 studies on the registry are indexed under Aortic Aneurysm; 117 are open to participants now.
This study's enrollment of 62 is close to the median of 62 across 318 interventional studies indexed under Aortic Aneurysm.
Browse Aortic Aneurysm studies →University of Washington is the lead sponsor of 1,397 studies on the registry; 225 are open to participants now.
Of its 154 completed or terminated interventional studies of FDA-regulated products, 132 (86%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Reduced Contrast Dual Energy CT
Other: Reduced contrast DECT scan · Other: Standard contrast SECT scan
Subjects will undergo a dual energy CT scan with reduced contrast
Subjects will undergo standard of care single energy CT scan with a standard dose of contrast. (control)
Diagnostic ability determined by image quality (subjective and objective evaluation of vessel attenuation and depiction, image noise, image quality and information from virtual non-contrast
Time frame: Up to 24 months
This study is completed, as verified in May 2018. You cannot join it, but the record below documents what was studied.
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