A Phase 4 interventional study of Parecoxib sodium and Normal saline injection in Pain, Postoperative, sponsored by Peking Union Medical College Hospital. Completed at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2015-08-28.
Sponsored by Peking Union Medical College Hospital · Phase 4, Interventional, and Treatment
Evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.
Non-steroid anti-inflammatory drugs are recommended for multimodal postoperative pain management.
We evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's enrollment of 74 is close to the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Peking Union Medical College Hospital is the lead sponsor of 1,115 studies on the registry; 463 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The patients in the parecoxib group received a single 40mg dose of parecoxib sodium 30 minutes before incision.
Drug: Parecoxib sodium
The control group received 2 mL normal saline injection at the same time point.
Drug: Normal saline injection
The patients in the parecoxib group received a single 40mg dose of parecoxib sodium 30 minutes before incision, 9:00 pm on the operation day as well as 9:00 am and 9:00 pm for the next two days after the operation, along with PCIA morphine.
Also known as: Dynastat
The patients in the control group received 2 mL normal saline injection 30 minutes before Normal saline injection incision, 9:00 pm on the operation day as well as 9:00 am and 9:00 pm for the next two days after the operation, along with PCIA morphine.
Also known as: Physiological saline
To evaluate the Morphine consumption in each group patients
Time frame: 4 hours to 6 days after the surgery
To evaluate Patient-Controlled Intravenous Analgesia (PCIA) duration
Time frame: 4 hours to 6 days after the surgery
To evaluate the Visual Analog Scale (VAS) in each group patients underwent total knee arthroplasty and total hip arthroplasty
Time frame: 4 hours to 6 days after the surgery
Function recovery of knee Range of Motion (ROM) for patients received surgery
Time frame: 3 and 6 days after the surgery
Testing of body temperature,routine blood examination, IL-6 and IL-10
Time frame: hospital admission and 1, 3, 6 days after the surgery
This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Peking Union Medical College Hospital