An observational study in Attention Deficit Hyperactivity Disorder, sponsored by National Taiwan University Hospital. Completed at 1 site in Taiwan. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-03-18.
Sponsored by National Taiwan University Hospital · Observational
Attention deficit/hyperactivity disorder (ADHD) is a common, impairing, childhood onset neuropsychiatric disorder with executive dysfunctions. The ADHD symptoms and executive deficits may last to adulthood. Our previous studies, like western results, have shown that children with ADHD have disrupted microstructural integrity of frontostriatal fiber pathways and impaired brain activity in frontoparietal network. However, there is lack of data with regards to whether adults with ADHD also demonstrate structural and functional disconnectivity of frontostriatal and frontoparietal networks as compared to healthy controls without ADHD in Asian population and no study has been done to correlate a wide range of executive functions with the connectivity of these two networks.
Specific Aims:
729 studies on the registry are indexed under Hyperkinesis; 25 are open to participants now.
This study's enrollment of 90 is below the median of 134 across 122 observational studies indexed under Hyperkinesis.
Browse Hyperkinesis studies →National Taiwan University Hospital is the lead sponsor of 2,563 studies on the registry; 569 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
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The sample consists of 50 adults (ages 18-45) with clinical diagnosis of ADHD according to the DSM-IV criteria and 50 age-, sex-, and IQ-matched healthy controls without lifetime diagnosis with ADHD.
Exclusion Criteria:
Adults with clinical diagnosis of ADHD according to the DSM-IV criteria
Age-, sex-, and IQ-matched healthy controls without lifetime diagnosis with ADHD
Structural neuroimaging
Using diffusing spectrum imaging (DSI) to assess the structural connectivity in frontostriatal, frontoparietal and other circuitries.
Time frame: one day
Functional connectivity of the brain circuits
Using resting-state functional MRI (rsfMRI) to assess the functional connectivity in frontostriatal, frontoparietal and other circuitries.
Time frame: one day
This study is completed, as verified in Mar 2015. You cannot join it, but the record below documents what was studied.
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National Taiwan University Hospital