An interventional study of Sevoflurane and TIVA in High Sensitive Troponin T Release, sponsored by Dr. Horst Schmidt Klinik GmbH. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-08-03.
Sponsored by Dr. Horst Schmidt Klinik GmbH · Not applicable, Interventional, and Prevention
It has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties. This has been shown in animal studies and in patients that underwent cardiac surgery. The aim of our study is to examine if Sevoflurane, a volatile anaesthetic, has this properties in patients undergoing lung surgery.
1,916 studies on the registry are indexed under Hypersensitivity; 265 are open to participants now.
This study's enrollment of 100 is above the median of 57 across 1,384 interventional studies indexed under Hypersensitivity.
Browse Hypersensitivity studies →Dr. Horst Schmidt Klinik GmbH is the lead sponsor of 12 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
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Patients receive Sevoflurane 1 MAC (minimal alveolar concentration) after induction of anesthesia with propofol, remifentanil and atracurium for 30 minutes as preconditioning.
Drug: Sevoflurane
Patients received the standard total intravenous anesthesia (TIVA) with propofol, remifentanil and atracurium.
Drug: TIVA
Anaesthesia is induced (1-2 mg/kg) and maintained (5-7 mg/kg/h) with propofol and remifentanil (1 µg/kg and 0,2-0,4 µg/kg/min). After induction of anesthesia the propofol infusion is stopped and patients receive 1 MAC Sevoflurane over 30 min. Then the propofol infusion is restarted and Sevoflurane is washed out.
Anaesthesia is induced (1-2 mg/kg) and maintained (5-7 mg/kg/h) with propofol and remifentanil (1 µg/kg and 0,2-0,4 µg/kg/min).
Also known as: Placebo, Controll
Troponin T
assessing a change in high sensitive Troponin T (5th generation) Level before and at six time points after surgery (right after surgery, every 8 hours up to 40 hours after surgery)
Time frame: change of Troponin T levels preoperative and postoperative up to 40 hours after surgery
This study is completed, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.
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Dr. Horst Schmidt Klinik GmbH