A Phase 4 interventional study of Clomiphene citrate and Estradiol and Clomiphene citrate and Placebo in Infertility and Anovulation, sponsored by Maher elesawi kamel elesawi. Status unknown at 3 sites in Egypt. Open to female participants aged 20 Years to 39 Years. Per ClinicalTrials.gov, last updated 2017-03-22.
Sponsored by Maher elesawi kamel elesawi · Phase 4, Interventional, and Treatment
Among 33 studies testing clomiphene in Infertility — 1 open to participants now, 4 under way, 1 of them phase 3. Clomiphene · Infertility.
Among the 33 studies testing clomiphene in Infertility, this one is the 4th largest by planned enrollment, is one of 2 that started in 2014, is one of 19 in phase 4, and was the 19th registered.
2,085 studies on the registry are indexed under Infertility; 357 are open to participants now.
This study's planned enrollment of 600 is above the median of 135 across 1,412 interventional studies indexed under Infertility.
Browse Infertility studies →1 of the 33 studies testing clomiphene in Infertility is open now, in 1 country. Each count lists the studies.
Clomiphene: first FDA approval 1967 (CLOMID). What it is approved for, and how studies give it, is on its page →
Of the 235 Infertility studies recruiting now, 43 (18%) set no upper age limit and 186 (79%) stop at 75 or younger; 27 take children under 18; 78 take healthy volunteers.
This study: 20 Years to 39 Years · female · no healthy volunteers.
The full table on the hub →33 studies; the count open now beside each. This study's row is marked.
First in 1991; this study’s year is marked. 2 started in 2014.
Median enrollment 154 across the 33 interventional studies. Of the 18 that completed or were terminated, 6 (33%) have results posted.
1 of 33 have an industry lead sponsor. The 10 most frequent:
Maher elesawi kamel elesawi is the lead sponsor of 2 studies on the registry; none are open to participants now.
Maher elesawi kamel elesawi has 1 study filed under Infertility — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 33 studies testing clomiphene in Infertility, from their registry updates:
Nothing recorded among them since 2026-09-25.
The purpose of this study is to evaluate the effect of concomitant administration of estradiol during use of clomiphene citrate (CC) for induction of ovulation in infertile women.
Women will be randomly divided into two groups; CC-E2 group and CC group. Women in the CC-E2 group will receive CC (100 mg/day for 5 consecutive days from day 2 of cycle) and estradiol (2 mg/day for 5 consecutive days from day 2 of cycle). Women in the CC group will receive CC (100 mg/day for 5 consecutive days from day 2 of cycle) and placebo mimic estradiol (for 5 consecutive days from day 2 of cycle). Transvaginal sonography (TVS) scan will be performed regularly for monitoring of follicular growth (folliculometry); starting from day 10 of the stimulation cycle and repeated every 2-3 days. When there will be at least one follicle ≥ 18 mm in diameter, final oocyte maturation will be induced by intramuscular administration of 10000 IU of human chorionic gonadotropin (HCG) and timed intercourse will be advised. If there will be no follicle ≥ 12 mm by day 16 of the cycle, monitoring of follicular growth will be discontinued and the cycle will be presumed to be anovulatory. Ovulation will be documented by TVS scan one week after triggering of oocyte maturation and will be confirmed by assessing the midluteal serum progesterone level. Each woman will be subjected to ovarian stimulation for a maximum of 3 consecutive cycles except if she gets pregnant in the first or second cycle.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Women will receive clomiphene citrate and estradiol
Drug: Clomiphene citrate and Estradiol
Women will receive clomiphene citrate and placebo
Drug: Clomiphene citrate and Placebo
Drug pages: Clomiphene · Estradiol
Women will receive clomiphene citrate (100 mg/day for 5 consecutive days from day 2 of cycle) and estradiol (2 mg/day for 5 consecutive days from day 2 of cycle)
Also known as: Clomid and Estradiol valerate
Women will receive clomiphene citrate (100 mg/day for 5 consecutive days from day 2 of cycle) and placebo (for 5 consecutive days from day 2 of cycle)
Also known as: Clomid and Placebo
Clinical pregnancy rate
Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 6-8 weeks gestational age) divided by the number of women
Time frame: 6-8 weeks gestational age
Endometrial thickness on day of HCG administration
Endometrial thickness by TVS on day of HCG administration
Time frame: 3 months
Ovulation rate
Number of ovulatory cycles divided by the number of stimulation cycles
Time frame: 3 months
Number of ovarian follicles ≥ 18 mm on day of HCG administration
Number of ovarian follicles ≥ 18 mm by TVS on day of HCG administration
Time frame: 3 months
Plan to share: Undecided
No publications or documents are linked to this record.
The record gives a start of Jun 2014, a primary completion of Jul 2018 and a completion of Aug 2018. It does not say whether these dates are actual or estimated.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Clomiphene · Estradiol
Maher elesawi kamel elesawi