An observational study in Central Nervous System Complications of Anesthesia and Impaired Cognition, sponsored by KK Women's and Children's Hospital. Status unknown at 2 sites in Singapore. Open to participants aged 1 Day to 15 Months, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-02-21.
Sponsored by KK Women's and Children's Hospital · Observational
This prospective cohort study aims to determine if apparently healthy children with no significant co-morbidities who undergo general anaesthesia for minor surgery before 15 months of age will develop measurable deficits in neurocognitive development compared to apparently healthy children with no significant co-morbidities who do not undergo general anaesthesia or surgery.
We hypothesize that healthy children exposed to general anaesthesia for minor surgery before 15 months of age will have significantly lower neurocognitive scores at 6,18, 24 and 36 months of age compared with age, and gender matched healthy children from the GUSTO cohort without prior exposure to general anaesthesia or surgery. (GUSTO: Growing Up Towards Healthy Outcomes in Singapore: a prospective longitudinal study providing normative data from the local population).
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This study's enrollment of 250 is above the median of 150 across 950 observational studies indexed under Cognitive Dysfunction.
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Full-term infants with no significant co-morbidities presenting for minor surgery at KK Womens' and children's hospital, Singapore
Exclusion Criteria:
Exposure to general anaesthesia below 15 months of age
Children not exposed to general anaesthesia or surgery from GUSTO cohort. (GUSTO: Growing Up Towards Healthy Outcomes in Singapore: a prospective longitudinal study providing normative data from the local population)
Neurocognitive Assessment: Bayley's Scale of Infant Development-III
Bayley's Scale of Infant Development-III
Time frame: 24 months of age
Neurocognitive Assessment: Deferred Imitation
Deferred imitation is used to assess declarative memory
Time frame: 6 and 18 months of age
Neurocognitive Assessment: Habituation
Determines if an infant shows 'novelty preference' when stimuli are shown repeatedly.
Time frame: 6 and 18 months of age
Behavioural Assessment: Child behaviour checklist
Time frame: 24 months of age
Event Related Potential
Auditory Oddball
Time frame: 6 and 18 months of age
Visual Expectation
Time frame: 6 and 18 months of age
This study is status unknown, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.
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KK Women's and Children's Hospital