An interventional study of open surgical procedure and laparoscopic surgical procedure in Portal Hypertension and Liver Cirrhosis, sponsored by Second Affiliated Hospital of Xi'an Jiaotong University. Status unknown at 1 site in China. Per ClinicalTrials.gov, last updated 2014-06-30.
Sponsored by Second Affiliated Hospital of Xi'an Jiaotong University · Not applicable, Interventional, and Treatment
Many patients with portal hypertension require surgical treatment each year,and Hassab's operation, or esophagogastric devascularization and splenectomy, is an elective procedure. In recent years,laparoscopic esophagogastric devascularization and splenectomy has been used to treat portal hypertension. However, the potential benefits remain to be demonstrated in the context of a randomized trial. In this study, 120 patients will randomize equally receiving laparoscopic or open esophagogastric devascularization and splenectomy. Inclusion criteria included: platelet count \< 50×109/ml, esophageal and gastric varices revealed, agreeing the informed consent. PerioperativeOutcomes are: technical success, blood loose and infusion during the operation, recurrent varicose veins on gastroscopy examination, patterns of reflux on duplex ultrasound examination, complications, platelet and liver function variation, length of hospital stay. Follow-up will last 5 years, and gastroscopy and ultrasonic will perform at 3 months, 1 year, 3 years, and 5 years. Further more, this study was proved by the ethical committee of second hospital of Xi'an jiaotong university.
1,642 studies on the registry are indexed under Liver Cirrhosis; 358 are open to participants now.
This study's planned enrollment of 120 is above the median of 72 across 995 interventional studies indexed under Liver Cirrhosis.
Browse Liver Cirrhosis studies →Second Affiliated Hospital of Xi'an Jiaotong University is the lead sponsor of 68 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
the patients under go the open esophagogastric devascularization and splenectomy
Procedure: open surgical procedure
the patients under go the laparoscopic esophagogastric devascularization and splenectomy
Procedure: laparoscopic surgical procedure
open esophagogastric devascularization and splenectomy will perform as surgical procedure in the patients
laparoscopic esophagogastric devascularization and splenectomy will perform as surgical procedure in the patients
recurrence
gastroesophageal varices recurrence rate
Time frame: 5 years
operation time
Duration of surgical procedure
Time frame: 1 day
blood loss during surgical procedure
Time frame: 1 day
blood transfusion during surgical procedure
Time frame: 1 day
Number of Participants with Serious and Non-Serious Adverse Events
record all kind of postoperative complications in each patient
Time frame: 4 weeks
rebleeding
record rebleeding time in each bleeding patient
Time frame: 1 day
cost of hospitalization
Time frame: 4 weeks
survival
record the time of death and the death reason
Time frame: 5 years
length of hospital stay
Time frame: 4 weeks
This study is status unknown, as verified in Jun 2014. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital of Xi'an Jiaotong University