An interventional study of Saturated fat and Monounsaturated fat in Cardiovascular Disease, sponsored by University of Reading. Completed at 1 site in United Kingdom. Open to female participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-12-03.
Sponsored by University of Reading · Not applicable, Interventional, and Prevention
Cardiovascular disease (CVD) is the leading cause of death in women. Premenopausal women have a lower risk of CVD compared with men of a similar age. However, the incidence of CVD increases greatly after the menopause. The risk of heart disease is strongly associated with the health of an individual's blood vessels. It is thought that changes to the type of fat the investigators eat in their diet may affect the normal functioning and elasticity of the blood vessels, as well as affect cholesterol levels in the blood. Types of fat in the diet include monounsaturated fats (found mainly in olive oil), n-6 polyunsaturated fats (found mainly in sunflower oil) and saturated fats (found mainly in dairy products, such as butter and cheese). Since the investigators are in the fed (or postprandial) state for up to 18 hours of the day, it is important to see how these different fats affect the investigators blood vessels and blood fats over the course of the day after eating a meal. The aim of this study is to determine how consuming meals rich in saturated fats, n-6 polyunsaturated fats or monounsaturated fats influence the normal functioning and elasticity of the blood vessels throughout the day in postmenopausal women. A secondary aim is to determine the effects of these different dietary fats on a range of accepted heart disease risk markers including circulating levels of fats (lipids) and glucose in the blood.
4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.
This study's enrollment of 32 is below the median of 100 across 2,738 interventional studies indexed under Cardiovascular Diseases.
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Exclusion Criteria:
Subjects are asked to consume a breakfast (0 min) and lunch (330 min) rich in saturated fats
Dietary Supplement: Saturated fat
Subjects are asked to consume a breakfast (0 min) and lunch (330 min) rich in monounsaturated fats
Dietary Supplement: Monounsaturated fat
Subjects are asked to consume a breakfast (0 min) and lunch (330 min) rich in n-6 polyunsaturated fats
Dietary Supplement: n-6 polyunsaturated fat
Also known as: SFA
Also known as: MUFA
Also known as: n-6 PUFA
Change from baseline in vascular reactivity measured by flow-mediated dilatation (FMD)
Time frame: Acute study: measured at 0 (baseline), 180, 300 and 420 min
Change from baseline in vascular reactivity measured by laser Doppler imaging with iontophoresis of acetylcholine (endothelium-dependent) and sodium nitroprusside (endothelium-independent)
Time frame: Acute study: measured at 0 (baseline), 240 and 450 min
Change from baseline in plasma lipids (primarily triacylglycerol, apolipoprotein B and non-esterified fatty acids)
Time frame: Acute study: taken at 30 min intervals between 0 min (baseline) and 480 min
Change from baseline in arterial stiffness measured by digital volume pulse (stiffness index and reflection index)
Time frame: Acute study: taken at 0 (baseline), 240 amd 450 min
Change from baseline in blood pressure (systolic blood pressure, diastolic blood pressure and pulse pressure)
Time frame: Acute study: taken at 0 (baseline), 240 and 450 min
Change from baseline in markers of insulin resistance (glucose, insulin, indices of insulin resistance/sensitivity)
Time frame: Acute study: taken at 30 min intervals between 0 min (baseline) and 480 min
Change from baseline in nitric oxide (total plasma nitrates and nitrites)
Time frame: Acute study: 0 (baseline), 180, 300 and 420 min
Change from baseline in plasma markers of endothelial activation (e.g. E-selectin, P-selectin, vascular cell adhesion molecule (VCAM-1))
Time frame: Acute study: 0 (baseline), 180, 300 and 420 min
Change from baseline in plasma phospholipid fatty acid composition
Time frame: Acute study: 0 (baseline), 180, 300 and 420 min
This study is completed, as verified in Dec 2015. You cannot join it, but the record below documents what was studied.
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University of Reading