An interventional study of Timolol and Brimonidine in Intraocular Pressure Change in Intravitreal Injection, sponsored by Mashhad University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 40 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-05-16.
Sponsored by Mashhad University of Medical Sciences · Not applicable, Interventional, and Prevention
To assess the effect of prophylactic antiglaucoma agents in prevention of acute intraocular pressure rise after intravitreal injection.
Acute intraocular pressure elevation after intravitreal injection of bevacizumab was proven.Acute intraocular pressure elevation most probably is volume related and long term intraocular pressure elevation relates to pharmacologic features of the medications which results in anatomic changes in the angle of anterior chamber.Numerous studies found an intraocular pressure elevation right after the injection and quick normalization within maximally 30 minutes.This intraocular pressure elevation which lasts about 30 minutes, can result in irreversible visual loss especially in patients with critical remaining nerve fibers in the optic nerve head, as occurs in glaucomatous patients. Is there any way to prevent or even shorten this time of intraocular pressure elevation? We tried in our study to find a suitable response for a question above, so we used several anti-glaucoma agents (Timolol, Brimonidine, Acetazolamide, Mannitol versus placebo) as a prophylaxis to prevent acute intraocular pressure elevation right after intravitreal bevacizumab injection.
Mashhad University of Medical Sciences is the lead sponsor of 90 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Timolol eyedrop, 2 drops 5 minutes apart, 1-2 hours before intravitreal injection
Drug: Timolol
Brimonidine eyedrop, 2 drops 5 minutes apart, 1-2 hours before intravitreal injection
Drug: Brimonidine
Acetazolamide tablet, 2 tabs, 2 hours before intravitreal injection
Drug: Acetazolamide
Intravenous mannitol, 1.5 gram/kg, 1 hour before intravitreal injection
Drug: Mannitol
Artificial tears, 2 drops, 1-2 hours before intravitreal injection
Drug: Placebo
2 drops of timolol, 10 minutes apart, 1-2 hours before intravitreal injection
Also known as: Timoptic
Brimonidine eyedrop, 2 drops 5 minutes apart, 1-2 hours before intravitreal injection
Also known as: Alphagan
Acetazolamide tablet, 2 tabs, 2 hours before intravitreal injection
Also known as: Diamox
Intravenous mannitol, 1.5 gram/kg, 1 hour before intravitreal injection
Artificial tears, 2 drops, 1-2 hours before intravitreal injection
Also known as: Sham
change in IOP
the change in intraocular pressure after intravitreal injection of bevacizumab
Time frame: 0, 5, 10, 15, 30 minutes after injection
This study is completed, as verified in May 2014. You cannot join it, but the record below documents what was studied.
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Mashhad University of Medical Sciences