An interventional study of Noninvasive ventilation in Haemodynamic Rebound, sponsored by Federal University of Uberlandia. Completed at 1 site in Brazil. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-09-15.
Sponsored by Federal University of Uberlandia · Not applicable, Interventional, and Basic science
The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for safety and effectiveness of the technique application.
The main objective of this research is to evaluate the hemodynamic repercussions using doppler echocardiography in healthy volunteers submitted a different values of positive end expiratory pressure (PEEP) by the following ventilatory modes: Continuous positive airway pressure (CPAP) and Bilevel.
The study hypothesis is that the positive end expiratory pressure (PEEP) may cause hemodynamic repercussions as: reduction of the ventricles pre-load, left ventricle after load, cardiac output and reduction in the diameter of the superior vena cava, due to the increase in the intrathoracic pressure and pulmonary volumes.
Federal University of Uberlandia is the lead sponsor of 59 studies on the registry; 3 are open to participants now.
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The volunteers initially underwent a clinical examination, spirometry and echocardiography to prove the health state. Then, different levels of positive end expiratory pressure (PEEP) is applied by the noninvasive ventilation in all individuals and the hemodynamic repercussions are evaluated by the doppler echocardiography
Other: Noninvasive ventilation
Assess the hemodynamic repercussions of the positive end expiratory pressure applied noninvasively
Also known as: Continuos positive airway pressure, Bilevel, Positive end expiratory pressure
Hemodynamic repercussions of different levels of positive end expiratory pressure applied noninvasively, measured by echocardiography
The hemodynamic variables evaluated are: ventricular preload, left ventricle afterload, cardiac output, blood pressure and the vena cava's diameter. All variables will be assessed by echocardiography
Time frame: 5 minutes
Measurement of cardiac output as a predictor of cardiopulmonary adaptation to different pressures.
Time frame: 5 minutes
Difference between the hemodynamic effects generated by ventilation modes CPAP and Bilevel
Time frame: 3 hours
This study is completed, as verified in Sep 2015. You cannot join it, but the record below documents what was studied.
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Federal University of Uberlandia