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CompletedNCT02129179Updated Apr 5, 2018

The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure

A Phase 1 interventional study of Glucagon-Like Peptide 1 in Heart Failure, sponsored by Papworth Hospital NHS Foundation Trust. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-04-05.

Sponsored by Papworth Hospital NHS Foundation Trust · Phase 1, Interventional, and Basic science

Phase
Phase 1
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

This study aims to assess the effect of glucagon-like peptide-1 on cardiac output and transpulmonary gradient in patients undergoing right heart catheterisation for clinical reasons.

02

Conditions studied

  • Heart Failure

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03

In context

Heart Failure

5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.

This study's enrollment of 10 is below the median of 72 across 3,736 interventional studies indexed under Heart Failure.

Browse Heart Failure studies →

Lead sponsor

Papworth Hospital NHS Foundation Trust is the lead sponsor of 62 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age over 18
  • Able to give informed consent
  • On the waiting list for heart transplant
  • Left Ventricular Dysfunction awaiting catheterisation

Exclusion criteria

Exclusion Criteria:

  • Nicorandil, glibenclamide, Dipeptidyl Peptidase-4 inhibitor, Glucagon-Like Peptide-1 receptor agonist or insulin
  • Women of child bearing age and breast feeding women
  • Cardiac pacemaker or other implanted metallic device
  • Unable to give informed consent
05

Study design

Phase
Phase 1
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (actual)

Study arms

  • Experimental
    GLP-1

    Drug: Glucagon-Like Peptide 1

Interventions

  • DrugGlucagon-Like Peptide 1
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What researchers measure

Primary outcomes

  1. Change in Pulmonary Vascular Resistance with Glucagon-Like Peptide-1

    Time frame: 30 minutes

07

Study locations

1 site
  • Papworth Hospital NHS Foundation Trust
    Papworth Everard, CB23 3RE, United Kingdom
08

References and documents

Publications

  • Clarke SJ, Pettit S, Giblett JP, Zhao T, Kydd AC, Albrechtsen NJW, Deacon CF, Parameshwar J, Hoole SP. Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study. Clin Ther. 2019 Jan;41(1):118-127.e0. doi: 10.1016/j.clinthera.2018.11.013. Epub 2018 Dec 28. PubMed 30598343 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 5, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02129179
Lead sponsor
Papworth Hospital NHS Foundation Trust
Responsible party
Sponsor
First posted
May 2, 2014
Start date
Jun 2014
Primary completion
Dec 2016
Completion
Dec 2016
Last update
Apr 5, 2018

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2018. You cannot join it, but the record below documents what was studied.

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