An interventional study of Resistance training and Aerobic training in Chronic Inflammatory Demyelinating Polyneuropathy and Multifocal Motor Neuropathy, sponsored by University of Aarhus. Completed at 2 sites in Denmark. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2016-05-12.
Sponsored by University of Aarhus · Not applicable and Interventional
Resistance and aerobic exercise has been shown to be effective for maintenance of muscle strength in patients with neuromuscular diseases.
Exercise in CIDP and MMN is sparsely described. The aim of the study is to evaluate changes in muscle strength during high intensive resistance training and changes in maximal oxygen consumption (VO2-max) during high intensive aerobic training in patients with CIDP or MMN in maintenance therapy with subcutaneous immunoglobulin.
The hypotheses are that muscle strength and VO2-max are significantly increased during the training sessions.
256 studies on the registry are indexed under Polyneuropathies; 50 are open to participants now.
This study's enrollment of 23 is below the median of 75 across 162 interventional studies indexed under Polyneuropathies.
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Exclusion Criteria:
* Week -12 to 0: Run-in period with no training * Week 0 to 12: Aerobic training on ergometer bicycle * Week 12 to 24: Resistance training with dumbbells
Other: Resistance training · Other: Aerobic training
* Week -12 to 0: Run-in period with no training * Week 0 to 12: Resistance training with dumbbells * Week 12 to 24: Aerobic training on ergometer bicycle
Other: Resistance training · Other: Aerobic training
Participants do resistance training of selected muscle groups. Resistance are predefined from 1-repetition max (1-RM) and increased during the 12 weeks of training: * Week 0-4: 70-80 % of 1-RM * Week 5-8: 75-86 % of 1-RM * Week 9-12: 80-92% of 1-RM Participants trains unilateral, the opposite site serves as reference. * MMN patients train elbow (flexion/extension) and wrist (flexion/extension) * CIDP patients train knee (flexion/extension) and elbow (flexion/extension)
Participants train on ergometer bicycle 2 times weekly increasing during the first weeks to 3 times weekly. Workload is measured before initiation and VO2-max, heart rate and blood pressure will be measured as well. Patients train with 60-75 % of VO2-max for 30 minutes per training session. They use heart rate monitor to store data.
Changes in isokinetic muscle strength
Changes in isokinetic muscle strength during resistance exercise. Four muscle groups bilateral are selected. CIDP: Knee flexion/extension Elbow flexion/extension MMN: Elbow flexion/extension Wrist flexion/extension
Time frame: -12, 0, 6, 12 weeks or -12, 0, 12, 18, 24 weeks
Changes in maximal oxygen consumption (VO2-max)
VO2-max are measured during the 12 weeks aerobic exercise session and at enrolment 12 weeks before start of exercise. VO2-max are measured while the participant running on a ergometer bicycle by accumulation of exhaled air
Time frame: -12, 0, 6, 12 weeks or -12, 0, 12, 18, 24 weeks
Change in Medical Research Council (MRC)
Time frame: -12, 0, 6, 12, 18, 24 weeks
Change in Overall Disability Sum Score (ODSS)
Time frame: -12, 0, 6, 12, 18, 24 weeks
Change in 6-Minute Walk test
Time frame: -12, 0, 6, 12 weeks or -12, 0, 12, 18, 24 weeks
Change in Quality of Life measured by The Short Form (36) Health Survey (SF-36) questionnaire
Time frame: -12, 0, 6, 12, 18, 24 weeks
Change in Fatigue Severity Score (FSS)
Time frame: -12, 0, 6, 12, 18, 24 weeks
This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.
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University of Aarhus