An interventional study of Dexamethasone and Normal Saline in Chronic Pain, Dexamethasone and Thoracic Surgery, sponsored by Maisonneuve-Rosemont Hospital. Recruiting at 1 site in Canada. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-03-20.
Sponsored by Maisonneuve-Rosemont Hospital · Not applicable, Interventional, and Prevention
Post thoracotomy pain syndrome still affects 50% of patients after a thoracic surgery. Pathogenesis is unclear but there is growing evidence that neuro inflammation may play a significant role. Dexamethasone is a very potent anti-inflammatory drug. The hypothesis of this study is that dexamethasone, given pre operatively, would help reduce the incidence of post thoracotomy pain syndrome 3 months after surgery, by reducing the inflammatory response, in patients undergoing elective thoracic surgery that includes thoracic epidural analgesia.
2,930 studies on the registry are indexed under Chronic Pain; 701 are open to participants now.
This study's planned enrollment of 60 is close to the median of 60 across 2,161 interventional studies indexed under Chronic Pain.
Browse Chronic Pain studies →Maisonneuve-Rosemont Hospital is the lead sponsor of 70 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Dexamethasone 10 mg will be given as a single-dose, pre incision, intravenously
Drug: Dexamethasone
Patients in this group will receive 2.5 mL of normal saline intravenously, pre-incision
Drug: Normal Saline
10 mg (2.5 ml)
Also known as: decadron
2.5 mL normal saline
Also known as: Placebo
cytokine elevation
Time frame: 24 h after surgery
incidence of post thoracotomy pain syndrome
Time frame: 3 months after surgery
incidence of post thoracotomy pain syndrome
Time frame: 6 months after surgery
incisional and shoulder pain
Time frame: acute post operative period
Brief pain inventory questionnaire
Time frame: three months after surgery
Brief pain inventory questionnaire
Time frame: 6 months after surgery
Leeds Assessment of Neuropathic Signs and Symptoms questionnaire
Time frame: three and six months after surgery
cytokine elevation
Time frame: 1h after surgery
cytokine elevation
Time frame: 48 h after surgery
Plan to share: Yes
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Maisonneuve-Rosemont Hospital