Phase I Study to evaluate124I-A11 PSCA Minibody in Patients With Metastatic Prostate, Bladder and Pancreatic Cancer

Inclusion Criteria (subjects must meet all of the following criteria in order to be enrolled in this study):

1. Histological diagnosis of prostate, bladder or pancreatic cancer.
2. Evidence of recurrent metastatic disease demonstrated by an abnormal bone scan, CT scan or MRI, or FDG-PET within 6 weeks (with no new interval treatment before imaging trial)
3. Expected survival ≤ 6 months
4. Provide written informed consent and willing to comply with protocol requirement
5. ≥ 18 years of age

6. The following laboratory results should be within the following limits within 4 weeks prior to study day 1:

   1. PSA > 5 (only for prostate cancer patients)
   2. Absolute neutrophil count (ANC) ≥ 1.5 x 10\^9/l
   3. Platelet count ≥ 100 x 10\^9/l
   4. Serum bilirubin ≤ 2.0 mg/dl
   5. Aspartate amino transaminase (AST) ≤ 2.5 x ULN
   6. Alanine aminotransferase (ALT) ≤ 2.5 x ULN
   7. Serum creatinine ≤ 2.0 mg/dl (calculated creatinine clearance > 45 ml/min)
7. Able to undergo imaging studies, as well as conventional bone and body imaging, as well as 124I-A11 PSCA minibody experimental scan.

Exclusion Criteria (subjects meeting any of the following criteria will not be enrolled in this study):

1. Inadequate venous access (two antecubital or equivalent venous access sites)
2. Administration of a radionuclide within 5 physical half-lives prior to projected administration of 124I-A11 PSCA minibody
3. New York Heart Association Class III/IV cardiac disease.
4. History of autoimmune hepatitis
5. Treatment with any experimental therapy within 30 days prior to enrollment or current participation in any other interventional clinical study
6. Subjects weighing ≥ 350 lbs or are unable to fit in the imaging gantry
7. Any other condition or personal circumstance that, in the judgment of the investigator, might interfere with the collection of complete good quality data.
8. Iodine Allergy, hyperthyroidism, or Grave's disease.
9. Any other disease or medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study.