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CompletedNCT02081820Updated Mar 18, 2015

Admission HbA1C in Aneurysmal Subarachnoid Hemorrhage

An observational study in Hyperglycemia and Aneurysmal Subarachnoid Hemorrhage, sponsored by Heinrich-Heine University, Duesseldorf. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-03-18.

Sponsored by Heinrich-Heine University, Duesseldorf · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
89
Ages
18 Years and older
Sex
All
01

Study summary

In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture. In this patient registry admission HbA1c, clinical course and neurological outcome after 6 month are recorded, to determine whether elevated blood glucose levels prior to aneurysm rupture influence the clinical course and patient outcome after aSAH.

Read the detailed description

In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture.

In this patient registry admission HbA1c within 72 hours after confirmed aneurysmal subarachnoid hemorrhage in patients aged over 18 years is determined and correlated with clinical course and neurological outcome after 6 month as determined by modified Rankin score. Additionally, patients are monitored for incidence of delayed cerebral ischemia (DCI) and the incidence of new infarction on the discharge ct scan attributable to DCI. General treatment of cerebral aneurysm and subarachnoid hemorrhage in all patients follows international guidelines.

02

Conditions studied

  • Hyperglycemia
  • Aneurysmal Subarachnoid Hemorrhage

Keywords

  • hyperglycemia
  • aneurysmal subarachnoid hemorrhage
  • glycated hemoglobin
  • outcome
  • DCI
03

In context

Subarachnoid Hemorrhage

509 studies on the registry are indexed under Subarachnoid Hemorrhage; 124 are open to participants now.

This study's enrollment of 89 is below the median of 117 across 226 observational studies indexed under Subarachnoid Hemorrhage.

Browse Subarachnoid Hemorrhage studies →

Lead sponsor

Heinrich-Heine University, Duesseldorf is the lead sponsor of 174 studies on the registry; 52 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients with confirmed aneurysmal subarachnoid hemorrhage admitted within 72 hours to our department aged over 18 years.

Inclusion criteria

  • confirmed aneurysmal subarachnoid hemorrhage
  • admission within 72hours after hemorrhage
  • Age >18 years

Exclusion criteria

Exclusion Criteria:

  • non-aneurysmal SAH
  • admission >72hours after hemorrhage
  • Age \<18 years
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
89 participants (actual)
Target follow-up
6 Months
Patient registry
Yes

Groups and cohorts

  • aneurysmal subarachnoid hemorrhage

    observational, no intervention

06

What researchers measure

Primary outcomes

  1. modified Rankin score

    Time frame: 6 month after discharge

Secondary outcomes

  1. Incidence of DCI related new infarction on discharge ct scan

    Incidence of new infarction on discharge ct scan not attributable to causes other then DCI.

    Time frame: at discharge, approx. 14-21days after admission

07

Study locations

1 site
  • Department of Neurosurgery, Heinrich-Heine-University Düsseldorf
    Düsseldorf, NRW 40225, Germany
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 18, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT02081820
Lead sponsor
Heinrich-Heine University, Duesseldorf
Responsible party
Neurochirurgische Klinik, Universitätsklinikum Düsseldorf (Neurochirurgische Klinik, Universitätsklinikum Düsseldorf, Heinrich-Heine University, Duesseldorf) — Principal investigator
First posted
Mar 7, 2014
Start date
Jul 2012
Primary completion
Dec 2014
Completion
Dec 2014
Last update
Mar 18, 2015

Study contacts

Kerim Beseoglu, M.D.
principal investigator · Department of Neurosurgery, Heinrich-Heine-University, Düsseldorf

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Mar 2015. You cannot join it, but the record below documents what was studied.

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