CClinicalTrials.gg
CompletedNCT02039102Updated Jun 21, 2021

Contraceptive Use and Respiratory Conditions Among Scottish Women

An observational study in Asthma, sponsored by University of Edinburgh. Completed at 1 site in United Kingdom. Open to female participants aged 16 Years to 45 Years. Per ClinicalTrials.gov, last updated 2021-06-21.

Sponsored by University of Edinburgh · Observational

Study type
Observational
Model
Other
Time perspective
Cross-sectional
Enrollment
3,257
Ages
16 Years to 45 Years
Sex
Female
01

Study summary

Studies examining the sex differences in the epidemiology and morbidity patterns of asthma show that the rates of disease severity, healthcare utilisation, and poor quality of life are considerably higher in women than in men, and this has been attributed to endogenous and exogenous sex hormonal factors. Studies examining the impact of use of hormonal contraceptives on the risk of asthma and asthma-related conditions are few, yet findings are conflicting.

In the present study, the investigators utilize data from the Scottish Health Survey, a national representative sample, to investigate the associations between current use of hormonal contraceptives and the prevalence of self-reported doctor-diagnosed current asthma and wheezing symptoms in Scottish women. The investigators hypothesize that while current use of any hormonal contraceptives and combined oral pills are associated with higher prevalence of asthma and asthma outcomes, current use of progesterone-only contraceptives is not associated with asthma. A secondary aim of the current study is to examine whether there is evidence of any biological interaction between use of hormonal contraceptives and BMI in relation to the risk of asthma and asthma outcomes.

02

Conditions studied

  • Asthma

Browse trials for

Keywords

  • hormonal contraceptives
  • combined pills
  • progesterone-only contraceptives
  • body mass index
  • asthma
  • Scotland
  • women
03

In context

Asthma

3,921 studies on the registry are indexed under Asthma; 507 are open to participants now.

This study's enrollment of 3,257 is above the median of 150 across 970 observational studies indexed under Asthma.

Browse Asthma studies →

Lead sponsor

University of Edinburgh is the lead sponsor of 393 studies on the registry; 64 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
16 Years to 45 Years
Sexes eligible
Female
Sampling method
Probability sample

Study population

Non-pregnant women aged 16-45 years

Inclusion criteria

  • Non-pregnant
  • Woman
  • 16-45 years old

Exclusion criteria

Exclusion Criteria:

  • Pregnant
  • Man
  • Younger than 16 years or older than 45 years old
05

Study design

Observational model
Other
Time perspective
Cross-sectional
Enrollment
3,257 participants (actual)
Patient registry
No

Groups and cohorts

  • Non-users of hormonal contraceptives
  • Users of hormonal contraceptives
06

What researchers measure

Primary outcomes

  1. Self-reported doctor-diagnosed current asthma

    Time frame: During the past 12 months

Secondary outcomes

  1. Self-reported wheezing symptom

    Time frame: During the past 12 months

  2. Self-reported current treatment for asthma/wheeze

    Time frame: During the past 12 months

07

Study locations

1 site
  • University of Ediburgh
    Edinburgh, United Kingdom
08

References and documents

Publications

  • Macsali F, Real FG, Omenaas ER, Bjorge L, Janson C, Franklin K, Svanes C. Oral contraception, body mass index, and asthma: a cross-sectional Nordic-Baltic population survey. J Allergy Clin Immunol. 2009 Feb;123(2):391-7. doi: 10.1016/j.jaci.2008.10.041. Epub 2009 Jan 3. PubMed 19121863 ↗
  • Lange P, Parner J, Prescott E, Ulrik CS, Vestbo J. Exogenous female sex steroid hormones and risk of asthma and asthma-like symptoms: a cross sectional study of the general population. Thorax. 2001 Aug;56(8):613-6. doi: 10.1136/thorax.56.8.613. PubMed 11462063 ↗
  • Salam MT, Wenten M, Gilliland FD. Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women. J Allergy Clin Immunol. 2006 May;117(5):1001-7. doi: 10.1016/j.jaci.2006.02.004. PubMed 16675325 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 21, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02039102
Lead sponsor
University of Edinburgh
Responsible party
Sponsor
First posted
Jan 17, 2014
Start date
Dec 2013
Primary completion
Sep 2018
Completion
Sep 2018
Last update
Jun 21, 2021

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion