An interventional study of Cefazolin and Vancomycin in Infection and Closed Fractures, sponsored by University of Tennessee. Terminated at 1 site in United States. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2018-07-11.
Sponsored by University of Tennessee · Not applicable, Interventional, and Prevention
The purpose of this study is to compare the incidence rate of infection in surgical patients with closed fractures treated prophylactically with Cefazolin versus Vancomycin in the peri-operative period.
The hypothesis of this study is that patients undergoing surgical treatment for closed fractures who are treated prophylactically with Vancomycin will have a lower incidence rate of infection than patients who are treated prophylactically with Cefazolin.
2,093 studies on the registry are indexed under Infections; 364 are open to participants now.
This study's enrollment of 430 is above the median of 113 across 1,304 interventional studies indexed under Infections.
Browse Infections studies →University of Tennessee is the lead sponsor of 142 studies on the registry; 21 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 2 (29%) have results posted.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
intravenous, weight-based dose (1gm\<80kg, 2gm\>80kg), perioperatively
Drug: Cefazolin
intravenous, weight-based dose (1gm\<80kg, 2gm\>80kg), perioperatively
Drug: Vancomycin
incidence of infection
Time frame: one year
The record gives a start of Oct 2009, a primary completion of Jun 2015 and a completion of Dec 2017. It does not say whether these dates are actual or estimated.
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This study is terminated, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Cefazolin · Vancomycin