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CompletedNCT02018211Updated Jun 26, 2015

Neuromuscular Electrical Stimulation Via the Peroneal Nerve Reduces Muscle Soreness Following Intermittent Exercise

An interventional study of control and graduated compression socks in Delayed Onset Muscle Soreness, sponsored by Firstkind Ltd. Completed at 1 site in United Kingdom. Open to male participants aged 20 Years to 22 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-06-26.

Sponsored by Firstkind Ltd · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
21
Allocation
Not applicable
Ages
20 Years to 22 Years
Sex
Male
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Study summary

Numerous techniques are reported to enhance recovery following intense exercise, however there is equivocal support for such claims. A novel technique of neuromuscular electrical stimulation (NMES) via the peroneal nerve has been shown to augment limb blood flow which could enhance recovery following exercise. The present study examined the effects of NMES, compared to graduated compression socks on muscle soreness, strength, and markers of muscle damage and inflammation following intense intermittent exercise.

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Conditions studied

  • Delayed Onset Muscle Soreness

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Keywords

  • delayed onset muscle soreness
  • muscle damage
  • muscle function
  • inflammation
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In context

Myalgia

282 studies on the registry are indexed under Myalgia; 43 are open to participants now.

This study's enrollment of 21 is below the median of 44 across 241 interventional studies indexed under Myalgia.

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Lead sponsor

Firstkind Ltd is the lead sponsor of 22 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 22 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy males
  • currently playing intermittent sports (such as soccer, field hockey, rugby)
  • currently representing their respective sports at either university, county, national or international levels

Exclusion criteria

Exclusion Criteria:

  • unhealthy males
  • not currently playing intermittent sports (such as soccer, field hockey, rugby)
  • not currently representing their respective sports at either university, county, national or international levels
  • individuals indicating a history of cardiovascular, metabolic or haematological disorders
  • participants reporting a sedentary lifestyle of less than three 30-min physical activity sessions per week
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Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
21 participants (actual)

Study arms

  • Experimental
    experimental group

    All participants performed a modified version of the Loughborough Intermittent Shuttle Test (LIST; Nicholas et al, 2000), an exercise protocol designed to simulate the activity pattern characteristics of intermittent sports such as soccer. The LIST was performed on three occasions, at the same time of day, each separated by approximately four weeks. Following each exercise trial, one of three recovery interventions were applied, the order of which were randomly allocated.

    Other: control · Device: graduated compression socks · Device: neuromuscular electrical stimulation device

Interventions

  • Othercontrol

    passive recovery following exercise test

  • Devicegraduated compression socks

    graduated compression socks worn after test exercise

  • Deviceneuromuscular electrical stimulation device

    neuromuscular electrical stimulation device worn after test exercise

    Also known as: firefly device

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What researchers measure

Primary outcomes

  1. Perceived muscle soreness (PMS)

    perceived muscle soreness (PMS), often referred to as delayed onset muscle soreness (DOMS)

    Time frame: 72hrs

Secondary outcomes

  1. muscle strength

    Time frame: 72hrs

Other outcomes

  1. measurement of CK and LDH activity and IL-6, CRP and TBAR concentrations

    markers of muscle damage and inflammation following intense intermittent exercise

    Time frame: 72 hrs

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Study locations

1 site
  • School of Sport, Exercise and Health Sciences
    Loughborough, Leicestershire LE11 3TU, United Kingdom
08

References and documents

Publications

  • Ferguson RA, Dodd MJ, Paley VR. Neuromuscular electrical stimulation via the peroneal nerve is superior to graduated compression socks in reducing perceived muscle soreness following intense intermittent endurance exercise. Eur J Appl Physiol. 2014 Oct;114(10):2223-32. doi: 10.1007/s00421-014-2943-5. Epub 2014 Jul 11. PubMed 25011496 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 26, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02018211
Lead sponsor
Firstkind Ltd
Collaborators
Loughborough University
Responsible party
Sponsor
First posted
Dec 23, 2013
Start date
Dec 2012
Primary completion
Mar 2013
Completion
Mar 2013
Last update
Jun 26, 2015

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jun 2015. You cannot join it, but the record below documents what was studied.

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