An observational study in Chronic Kidney Disease, sponsored by King's College London. Completed at 3 sites in United Kingdom. Open to participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2020-11-06.
Sponsored by King's College London · Observational
Studies suggest that dietary omega-3 fatty acids influence the extent to which the time interval between each heart beat varies (heart rate variability; HRV). Low HRV is associated with increased risk of sudden cardiac death (SCD). The purpose of this research is to investigate the relationship between 24 hour parameters of HRV and blood omega-3 fatty acid levels in patients who have recently commenced haemodialysis.
3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.
This study's enrollment of 52 is below the median of 192 across 1,033 observational studies indexed under Kidney Diseases.
Browse Kidney Diseases studies →King's College London is the lead sponsor of 506 studies on the registry; 125 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients attending King's College Hospital and Guy's and St Thomas' Hospitals who have recently commenced haemodialysis treatment.
Exclusion Criteria:
Patients with stage 5 chronic kidney disease who have recently commenced haemodialysis treatment (within 6-10 weeks of starting treatment)
Erythrocyte eicsapentaenoic acid (EPA) + docosahexaenoic acid (DHA) content (% weight of total fatty acids)
Primary independent variable
Time frame: 6-10 wk after commencing haemodialysis treatment
24 hour heart rate variability (Triangular index and SDNN)
Primary dependent variables. Triangular index and SDNN are indicators of overall variability
Time frame: 6-10 weeks after commencing haemodialysis treatment
24 h heart rate variability - longer phase parameters
Parameters of longer phase HRV: LF, VLF and SDANN
Time frame: 6-10 weeks after commencing haemodialysis
24 h heart rate variability - short-phase parameters
RMSSD, pNN50, HF
Time frame: 6-10 weeks after commencing haemodialysis
Nocturnal heart rate variability - all parameters
SDNN, Triangular index, LF, HF, VLF, SDANN, RMSSD, pNN50 calculating during nocturnal sleep-time
Time frame: 6-10 weeks after commencing haemodialysis
Plasma EPA+DHA content (% weight of total fatty acids)
Time frame: 6-10 weeks after commencing haemodialysis6-10 weeks after commencing haemodialysis
Complications of haemodialysis in first 6 weeks of starting treatment
Incidence of problems with dialysis access, inadequate urea reduction ratio, amount of excess oedematous fluid removed, serious adverse events
Time frame: 0-6 weeks after commencing haemodialysis
Background dietary intakes
Food frequency questionnaire
Time frame: 6-10 weeks after commencing haemodialysis
History of sleep apnoea
Epworth Sleepiness scale and Berlin questionnaire, plus relevant medical history
Time frame: 6-10 weeks after commencing haemodialysis
Weight
Time frame: 6-10 weeks after commencing haemodialysis
Waist circumference
Time frame: 6-10 weeks after commencing haemodialysis
12 month average blood pressure
Time frame: 12 months prior to commencing haemodialysis treatment
Plasma lipids
Time frame: 6-10 weeks after commencing haemodialysis
C-reactive protein
Time frame: 6-10 weeks after commencing haemodialysis
Serum electrolytes
Sodium, potassium, calcium, phosphate
Time frame: 6-10 weeks after commencing haemodialysis
This study is completed, as verified in Nov 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
King's College London