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CompletedNCT02007460HiphopUpdated Dec 10, 2013

The Influence of High Impact Exercise on Musculoskeletal Health in Older Men

An interventional study of Exercise in Bone Strength and Neuromuscular Function, sponsored by Loughborough University. Completed at 1 site in United Kingdom. Open to male participants aged 65 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-12-10.

Sponsored by Loughborough University · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Randomized
Ages
65 Years to 80 Years
Sex
Male
01

Study summary

Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.

02

Conditions studied

  • Bone Strength
  • Neuromuscular Function
03

In context

Lead sponsor

Loughborough University is the lead sponsor of 71 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
65 Years to 80 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • Healthy community dwelling men of white european origin

Exclusion criteria

Exclusion Criteria:

  • BMI >30 kg/m2
  • History of strength training or recently ( previous 12 months) doing moderate physical activity (weight bearing, high impact)
  • Recent ( previous 12 months) or current medical or surgical problems likely to affect bone metabolism or provide contraindications to high impact exercise, balance or neuromuscular function
  • Any previous or existing lower back or limb problems that could be exacerbated by undertaking high impact exercise
  • Any history of diagnosed or symptomatic diseases likely to influence strength, power, bone or habitual activity (including osteomalacia or impaired liver/renal function and locomotor disease, hypertension) that influences bone or muscle or precludes exercise
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Single group
Masking
Single (Outcomes assessor)
Enrollment
50 participants (actual)

Study arms

  • Experimental
    Exercise leg

    Behavioral: Exercise

  • No intervention
    Control leg

Interventions

  • BehavioralExercise

    multidirectional unilateral hopping exercise

06

What researchers measure

Primary outcomes

  1. Change in femoral neck bone mineral density

    Time frame: baseline, 12 months

Secondary outcomes

  1. Change in cortical bone mineral content

    Time frame: baseline, 12 months

  2. Change in trabecular bone mineral content

    Time frame: baseline, 12 months

  3. Change in ground reaction force during hopping

    Time frame: baseline, 6 months, 12 months

  4. Change in electromyography of quadriceps during hopping

    Time frame: baseline, 6 months

  5. Change in postural sway amplitude (mm)

    Time frame: baseline, 6 months

  6. Change in leg press strength

    Time frame: baseline, 6 months

  7. Change in maximal isometric knee extensor strength

    Time frame: baseline, 6 months

  8. Change in tendon stiffness

    Time frame: baseline, 6 months

Other outcomes

  1. Serum 25 hydroxy vitamin D

    Time frame: baseline

  2. Change in body fat content

    Time frame: baseline, 12 months

  3. change in energy intake (MJ/d)

    Time frame: baseline, 12 months

  4. change in calcium intake

    Time frame: baseline, 12 months

07

Study locations

1 site
  • Loughborough University
    Loughborough, Leicestershire LE11 3TU, United Kingdom
08

References and documents

Publications

  • Allison SJ, Folland JP, Rennie WJ, Summers GD, Brooke-Wavell K. High impact exercise increased femoral neck bone mineral density in older men: a randomised unilateral intervention. Bone. 2013 Apr;53(2):321-8. doi: 10.1016/j.bone.2012.12.045. Epub 2013 Jan 3. PubMed 23291565 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 10, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02007460
Lead sponsor
Loughborough University
Collaborators
University Hospitals Leicester NHS Trust, UK, University Hospitals of Derby and Burton NHS Foundation Trust
Responsible party
Katherine Brooke-Wavell (Senior Lecturer in Human Biology, Loughborough University) — Principal investigator
First posted
Dec 10, 2013
Start date
Jan 2010
Primary completion
Jan 2012
Completion
Jan 2012
Last update
Dec 10, 2013

Study contacts

Katherine Brooke-Wavell, PhD
principal investigator · Loughborough University
Winston Rennie, MBBS
principal investigator · University Hospitals Leicester NHS Trust
Jonathan Folland, PhD
principal investigator · Loughborough University
Greg Summers, MD
principal investigator · Derby University Hospitals Trust

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.

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