ClinicalTrials.gg
CompletedNCT01979770Updated Jan 31, 2023

Early Life Nutritional Exposures and Long-term Health and Cognitive Outcomes

An observational study in Overnutrition and Undernutrition, sponsored by Mahidol University. Completed at 1 site in Thailand. Open to participants aged 13 Years to 16 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-01-31.

Sponsored by Mahidol University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
529
Ages
13 Years to 16 Years
Sex
All
01

Study summary

This study aims to investigate the relationship of the various exposures during infancy and childhood on later health and development of adolescents. Various exposures to be assessed include, but not limit to, nutritional status, body composition, energy expenditure, dietary intake, micronutrient status, breastfeeding, lifestyle, and other environment exposures.

The study will specifically aim to respond these research questions:

1.1 What are the factors associated with overweight, obesity, and stunted in adolescents? 1.2 What are the factors associated with increased risk of NCDs during adolescence? 1.3 What are the factors associated with cognitive functioning during adolescence? Since numerous variables were collected, additional research questions can be possibly studied or other interested variables can be included in the future.

Read the detailed description

A longitudinal data were collected in children in the northeast of Thailand beginning at 4-6 months of age and every 2 months through 10-12 months of age while children had been given iron and/or zinc supplementation. Biochemical, anthropometric, socio-demographic, feeding practices, and maternal characteristics data were collected. Children were followed up at 9 years of age to assess the long-term consequences of supplementation and early life nutrition on cognitive functioning and growth. There is a need to continue the follow-up of this study in order to address the association between early nutritional exposures and risks of cardio-metabolic dysfunction and cognitive and behavioral development later in childhood, adolescence and adulthood. Thus, we propose to follow-up these children during adolescence to assess the relationship of early life nutrition and exposures during infancy and childhood and outcomes including nutritional status, cognitive functioning, and risk for non-communicable diseases (NCDs). Findings from this study could provide awareness and information in developing policies and timely interventions to maintain optimal nutritional status throughout vulnerable life stages and reduce risks of NCDs and disabilities later in life.

02

Conditions studied

  • Overnutrition
  • Undernutrition

Keywords

  • Adolescent
  • Nutritional status
  • Body composition
  • Biochemical status
03

In context

Overnutrition

32 studies on the registry are indexed under Overnutrition; 5 are open to participants now.

Browse Overnutrition studies →

Lead sponsor

Mahidol University is the lead sponsor of 744 studies on the registry; 116 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
13 Years to 16 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Adolescents who participated in an intervention trial of iron and zinc supplementation and a follow-up study at 9 years of age in 3 rural districts in Khon Kaen province, northeast of Thailand.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Apparently healthy children

Exclusion criteria

Exclusion Criteria:

  • none
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
529 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Adolescents

    Adolescents who participated in an intervention trial of iron and zinc supplementation and a follow-up study at 9 years of age in 3 rural districts in Khon Kaen province, northeast of Thailand.

06

What researchers measure

Primary outcomes

  1. Body composition

    Body fat mass (kg), Body fat-free mass (kg) % body fat mass (%), % body fat-free mass (%)

    Time frame: 1 year

Secondary outcomes

  1. Cognition

    IQ scores (IQ point)

    Time frame: 1 year

Other outcomes

  1. Cardio-vascular fitness

    VO2max (L/min)

    Time frame: 1 year

07

Study locations

1 site
  • Institute of Nutrition, Mahidol University
    Salaya, Changwat Nakhon Pathom 73170, Thailand
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2013 to primary completion in Mar 2018, 62 months.

How these figures are worked out, and which studies are left out of them.

Registered
Jul 28, 2013
First posted
Nov 8, 2013
StartActual
Jan 1, 2013
Primary completionActual
Mar 21, 2018
CompletionActual
Mar 21, 2018
Last update
Jan 31, 2023
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jan 31, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01979770
Lead sponsor
Mahidol University
Responsible party
Tippawan Pongcharoen (Researcher, Mahidol University) — Principal investigator
First posted
Nov 8, 2013
Start date
Jan 1, 2013
Primary completion
Mar 21, 2018
Completion
Mar 21, 2018
Last update
Jan 31, 2023

Study contacts

Tippawan Pongcharoen, Ph.D.
principal investigator · Mahidol University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion