An observational study in Liver Cirrhosis, sponsored by National Taiwan University Hospital. Status unknown at 1 site in Taiwan. Open to participants aged 6 Months to 75 Years. Per ClinicalTrials.gov, last updated 2013-10-30.
Sponsored by National Taiwan University Hospital · Observational
The arterial system compliance is compromised in liver cirrhotic patients. Dynamic preload variables are either pressure-based (e.g.pulse pressure variation; PPV), flow-based (e.g. stroke volume variation; SVV), or volume-based (plethysmographic variability index; PVI). It is not yet clear that dynamic preload parameters based on which mechanism will be accurate to predict fluid responsiveness in the cirrhotic patients. Therefore, this study aimed to claried which dynamic preload parameters would be more accurate during the liver transplantation.
Fluid management is crucial during liver transplantation. Patients with cirrhosis and portal hypertension have an altered blood volume distribution and pooling in the splanchnic circulation. Excess administration of intravenous fluid may increase portal hypertension due to splanchnic venous congestion and may also aggravate coagulopathy by dilution. On the other hand, fluid restriction may risk systemic and especially renal hypoperfusion. Traditional static fluid parameter, such as central venous pressure, pulmonary artery occlusion pressure, have been reported inaccurate to predict fluid responsiveness. In comparison, the recent developed dynamic fluid parameters based on heart-lung interaction were reported to be good preload indicators in a variety of different surgical settings. However, the validity of such dynamic fluid parameters is highly dependent on The arterial system compliance is compromised in liver cirrhotic patients. Dynamic preload variables are either pressure-based (e.g.pulse pressure variation; PPV), flow-based (e.g. stroke volume variation; SVV), or volume-based (plethysmographic variability index; PVI). It is not yet clear that dynamic preload parameters based on which mechanism will be accurate to predict fluid responsiveness in the cirrhotic patients. Therefore, this study aimed to claried which dynamic preload parameters would be more accurate during the liver transplantation.
1,668 studies on the registry are indexed under Liver Cirrhosis; 360 are open to participants now.
This study's planned enrollment of 80 is below the median of 152 across 605 observational studies indexed under Liver Cirrhosis.
Browse Liver Cirrhosis studies →National Taiwan University Hospital is the lead sponsor of 2,608 studies on the registry; 573 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
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End stage liver disease patients scheduled for liver transplantation in National Taiwan University Hospital
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Compare intraoperative change of dynamic parameters after fluid loading: 1. pulse pressure variation 2. stroke volume variation 3. plethysmographic variation index
Change of cardiac index after fluid loading
Time frame: one day
Fluid responsiveness parameters: pulse pressure variation
Time frame: one day
Fluid responsiveness parameters: stroke volume variation
Time frame: one day
Fluid responsiveness parameters: plethysmographic variation index
Time frame: one day
Mean arterial pressure changes
Time frame: one day
Central venous pressure changes
Time frame: one day
Heart rate changes
Time frame: one day
This study is status unknown, as verified in Oct 2013. You cannot join it, but the record below documents what was studied.
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