An interventional study of Trendelenburg position in ARDS PATIENTS WITH HEMODYNAMIC INSTABILITY, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-19.
Sponsored by Hospices Civils de Lyon · Not applicable, Interventional, and Diagnostic
Preload dependence assessment is difficult during prone position, and to date, no hemodynamic parameters have been validated to rationalize fluid loading in that position. This study aims to validate several hemodynamic parameters, using continuous cardiac output by pulse contour analysis and transpulmonary thermodilution.
Hospices Civils de Lyon is the lead sponsor of 1,826 studies on the registry; 439 are open to participants now.
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Exclusion Criteria:
Procedure: Trendelenburg position
Area under ROC curve of the variation in continuous cardiac output during Trendelenburg position, to detect preload dependence
Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%
Time frame: 1 minute after Trendelenburg position onset.
Area under ROC curve of the variation in continuous cardiac output during end-expiratory occlusion to detect preload dependence
Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%
Time frame: 15 seconds after the onset of end-expiratory occlusion
Area under ROC curve of the respiratory variation in pulse pressure to detect preload dependence
Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%
Time frame: 1 minute after tidal volume increase to 8 ml/kg
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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Hospices Civils de Lyon