An interventional study of Dietary supplement: fatty acid and Dietary supplement: fatty acid in NAFLD, sponsored by University of Oxford. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-01-05.
Sponsored by University of Oxford · Not applicable, Interventional, and Basic science
High levels of fatty substances in the blood increase the risk of developing heart disease. Investigators know a lot about one of these fatty substances, cholesterol. However, there is another fatty substance in the blood called triglyceride. Investigators do not understand much about what regulates the rate at which the liver produces triglyceride and liberates it into the bloodstream after eating a meal(s). It is known that taking fish oil lowers the amount of blood triglyceride however, it remains unclear how this happens. Investigators will study if changes in liver fat metabolism, after taking fatty acids found in fish oil (n-3 fatty acids)can explain the lowering of blood triglyceride. Investigators also want to know if taking fish oil alters the amount of fat that accumulates within the liver.
Investigators will recruit men and women with no medical condition or relevant drug therapy that affects liver fat metabolism.
Purpose and design:
Investigators are asking the research question: "How do specific fatty acids, such as those found in fish ((n-3) fatty acids) influence postprandial liver fat metabolism?"
It is known that n-3 fatty acids lower plasma triglyceride concentrations but it remains unclear how this happens.
To address this research question investigators want to undertake detail physiological studies, in a randomised study where individuals will be studied before and after taking n-3 fatty acids or a placebo oil.
University of Oxford is the lead sponsor of 794 studies on the registry; 117 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
4g/day n-3 fatty acids for 8 weeks
Dietary Supplement: Dietary supplement: fatty acid
4g/day olive oil for 8 weeks
Dietary Supplement: Dietary supplement: fatty acid
Consumption of n-3 fatty acids for 8 weeks
Also known as: n-3 fatty acids (EPA and DHA)
Consumption of olive oil for 8 weeks.
Also known as: Olive oil
Plasma triglyceride concentrations
Investigators will measure plasma triglyceride concentrations at baseline and 8 weeks after taking n-3 fatty acids or a placebo.
Time frame: Eight weeks
Hepatic fatty acid partitioning
Investigators will measure the contribution of newly synthesised fatty acids and dietary fatty acids to triglyceride production and oxidation pathways in the liver at baseline and 8 weeks after taking n-3 fatty acids.
Time frame: Eight weeks
This study is completed, as verified in Jan 2017. You cannot join it, but the record below documents what was studied.
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University of Oxford