An interventional study of Intraoperative fluid therapy in Other Complications of Esophagostomy, sponsored by National Taiwan University Hospital. Terminated at 1 site in Taiwan. Open to participants aged 20 Years to 70 Years. Per ClinicalTrials.gov, last updated 2013-09-02.
Sponsored by National Taiwan University Hospital · Not applicable, Interventional, and Supportive care
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response and short-term outcome after esophagectomy and reconstruction.
Measurements: intraoperative Lung injury score, Lung water index, Pulmonary vascular Permeability Index Measurements: intraoperative and postoperative Plasma creatine, C reactive protein (CRP), lactate, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin-6 (IL-6), Interleukin-8 (IL-8)
National Taiwan University Hospital is the lead sponsor of 2,609 studies on the registry; 574 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
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Exclusion Criteria:
To Keep intraoperative pulse pressure variation above 18%.
Other: Intraoperative fluid therapy
To keep intraoperative pulse pressure variation below 13%.
Other: Intraoperative fluid therapy
Intraoperative fluid therapy is directed by pulse pressure variation to a setting value, above 18% or below 13%.
postoperative lung function, kidney function, inflammatory response
plasma creatinine, CRP, lactate, NGAL, IL-6, IL-8
Time frame: from introperative to postoperative day 2
postoperative short-term outcome
Respiratory complication, cardiovascular complication, acute renal failure, another complications
Time frame: the duration of hospital stay, about 4 weeks
The record gives a start of Mar 2013, a primary completion of Aug 2013 and a completion of Aug 2013. It does not say whether these dates are actual or estimated.
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This study is terminated, as verified in Mar 2013. You cannot join it, but the record below documents what was studied.
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