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CompletedNCT01906047Updated Jul 23, 2013

Impact of Chronic Air Pollution on Non-cystic Fibrosis Bronchiectasis

An observational study in Bronchiectasis, sponsored by Universitaire Ziekenhuizen KU Leuven. Completed at 1 site in Belgium. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2013-07-23.

Sponsored by Universitaire Ziekenhuizen KU Leuven · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
189
Ages
18 Years to 65 Years
Sex
All
01

Study summary

We aim at investigation the impact of chronic air pollution exposure on non-cystic fibrosis bronchiectasis outcome.

Read the detailed description
  • Patient files will be search for time of death and cause of death.
  • Other variables will be collected: bacterial culture results, therapy, gender, age, etc.
  • These data will be linked with pollution data: trafic load, distance to major road, etc.
02

Conditions studied

  • Bronchiectasis

Keywords

  • Non-cystic fibrosis bronchiectasis
03

In context

Bronchiectasis

369 studies on the registry are indexed under Bronchiectasis; 105 are open to participants now.

This study's enrollment of 189 is above the median of 160 across 133 observational studies indexed under Bronchiectasis.

Browse Bronchiectasis studies →

Lead sponsor

Universitaire Ziekenhuizen KU Leuven is the lead sponsor of 928 studies on the registry; 261 are open to participants now.

Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with a HRCT diagnosis of bronchiectasis and do not have a diagnosis of cystic fibrosis. They also need to have typical bronchiectatic disease (recurrent infections and sputum).

Inclusion criteria

  • HRCT diagnosis of bronchiectasis
  • recurrent infections or chronic sputum production
  • patients between 18 and 65 years old.

Exclusion criteria

Exclusion Criteria:

  • Cystic Fibrosis
  • Tumoral disease
  • Traction bronchiectasis due to interstitial lung disease
  • patients older than 65 years or younger than 18 years at recruitment
  • COPD
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
189 participants (actual)
Target follow-up
6 Years
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. Death

    From June 2006 till October 2012, enrolled patients' medical file will be screened if death has occurred. If so, cause of death will be search for in the patients' file.

    Time frame: 6 years

07

Study locations

1 site
  • UZ Leuven
    Leuven, Vlaams-Brabant 3000, Belgium
08

References and documents

Publications

  • Goeminne PC, Bijnens E, Nemery B, Nawrot TS, Dupont LJ. Impact of traffic related air pollution indicators on non-cystic fibrosis bronchiectasis mortality: a cohort analysis. Respir Res. 2014 Sep 3;15(1):108. doi: 10.1186/s12931-014-0108-z. PubMed 25183428 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 23, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01906047
Lead sponsor
Universitaire Ziekenhuizen KU Leuven
Responsible party
Dr. Lieven Dupont (Prof. Dr. Lieven Dupont, Universitaire Ziekenhuizen KU Leuven) — Principal investigator
First posted
Jul 23, 2013
Start date
Jun 2006
Primary completion
Oct 2012
Completion
Apr 2013
Last update
Jul 23, 2013

Study contacts

Lieven J Dupont, MD, PhD
principal investigator · UZ Leuven
Pieter C Goeminne, MD
principal investigator · UZ Leuven

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2013. You cannot join it, but the record below documents what was studied.

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