An interventional study of transcranial direct current stimulation and sham stimulation in Patients With Mild Cognitive Impairment, sponsored by Charite University, Berlin, Germany. Withdrawn at 1 site in Germany. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-05-14.
Sponsored by Charite University, Berlin, Germany · Not applicable, Interventional, and Treatment
The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).
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Device: transcranial direct current stimulation
Device: sham stimulation
the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI)
to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) increases cortical plasticity (measured via motor evoked potentials) compared to sham stimulation
Time frame: 1 week
Comparison of tDCS-induced changes on central cholinergic activity
to investigate weather the anodal transcranial direct current stimulation affect central cholinergic activity (measured via a TMS protocol) in MCI patients compared to sham stimulation
Time frame: 1 week
Comparison of tDCS-induced changes in learning success
tDCS-induced changes in learning success (performance in a motor learning paradigm in patients with MCI after tDCS vs. sham stimulation)
Time frame: 1 week
MR elastography
Comparison of viscoelastic parameters in cerebral MR elastography in patients with MCI
Time frame: 1 week
genetic polymorphism, ApoE4
optional assessment of genetic Apo4 epsilon status for assessment of differences in cortical plasticity and elasticity between Apo4 epsilon positive and negative participants
Time frame: once
This study is withdrawn, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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Charite University, Berlin, Germany