An interventional study of exercise and fructose in Healthy Subjects, sponsored by University of Lausanne. Completed at 1 site in Switzerland. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-06-04.
Sponsored by University of Lausanne · Not applicable, Interventional, and Basic science
A high fructose diet increases fasting and post-prandial triglyceride (TG) concentrations in sedentary healthy human subjects.These effects may be secondary to fructose-induced hepatic de novo lipogenesis. Recent evidence indicate that exercise can prevent fructose induced dyslipidemia.This study will evaluate
University of Lausanne is the lead sponsor of 54 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
exercice performed 90 min before 13C fructose meal ingestion
Other: exercise
exercise performed 90 min after 13C fructose meal ingestion
Other: exercise
no exercise
meals containing fructose, cream and whey proteins over 24 hours after a glycogen/intramyocellular lipid depleting exercise
Dietary Supplement: fructose
meals containing glucose, cream and whey proteins over 24 hours after a glycogen/intramyocellular lipid depleting exercise
Dietary Supplement: glucose
cycling at 100W during 60 min
isocaloric nutrition with fructose, cream and whey protein during the 24 hour following a glycogen/intramyocellular lipid depleting exercise
isocaloric nutrition with glucose, cream and whey protein during the 24 hour following a glycogen/intramyocellular lipid depleting exercise
Plasma triglyceride
measurement of total and VLDL-TG concentrations in study 1
Time frame: measurements in fasting conditions and every hour from 7:00 am to 4:00 pm (up to 9 hours)
intramyocellular lipids
Measurement by 1H-MRS in muscle vastus lateralis in study 2
Time frame: after glycogen/intramyocellular lipid depleting exercise and after 24 hour controlled feeding post exercise
Fructose conversion into lipids
Estimated from 13C palmitate-VLDL concentration
Time frame: measured from 7:00 am to 4:00 pm in study 1 (up to 9 hours)
Fructose conversion into glucose
measurements obtained from plasma 13C glucose concentrations and whole body glucose production measured by 6,6 d2 glucose in study 1)
Time frame: measured between 7:00 am and 4:oo pm (up to 9 hours)
intramyocellular glycogen concentrations
Measured by 1H-MRS in muscle vastus lateralis in study 2
Time frame: after glycogen/intramyocellular lipid depleting exercise and after 24 hour controlled feeding post exercise
fructose oxidation
Calculated from breath 13CO2 production
Time frame: measured from 7:00 am to 4:00 pm in study 1 (up to 9 hours)
exogenous lipid oxidation
Lipids ingested will be labeled with 13C-triolein, and exogenous lipid oxidation will be measured from breath 13CO2 production
Time frame: measured from 7:00 am to 4:00 pm in study 2 (up to 9 hours)
This study is completed, as verified in Jun 2014. You cannot join it, but the record below documents what was studied.
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University of Lausanne