An observational study in Insulin Resistance, sponsored by University of California, San Francisco. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-10.
Sponsored by University of California, San Francisco · Observational
The study hypothesis is that the means by which HCV induces glucose intolerance is through impairment of B-cell function and compensatory hyperinsulinemia in predisposed Latinos with insulin resistance and that HCV eradication improves these abnormalities. It is also hypothesized that moderate alcohol consumption impact insulin sensitivity and secretion with Latinos with or without HCV infection.
The study hypothesis is that the means by which HCV induces glucose intolerance is through impairment of B-cell function and compensatory hyperinsulinemia in predisposed Latinos with insulin resistance and that HCV eradication improves these abnormalities. This study addresses changes in the metabolic parameters over time. In addition, it is hypothesized that moderate alcohol consumption impacts insulin resistance and secretion and 30 patients with or without HCV who drink alcohol moderately will have discontinuation of alcohol use for 6 weeks and have metabolic testing before and after alcohol discontinuation.
1,960 studies on the registry are indexed under Insulin Resistance; 306 are open to participants now.
This study's planned enrollment of 250 is above the median of 80 across 339 observational studies indexed under Insulin Resistance.
Browse Insulin Resistance studies →University of California, San Francisco is the lead sponsor of 2,132 studies on the registry; 375 are open to participants now.
Of its 262 completed or terminated interventional studies of FDA-regulated products, 196 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Latinos with and without HCV infection
Inclusion criteria for healthy Latino volunteers (without HCV infection):
-Same inclusion criteria as above except no evidence of HCV infection (anti-HCV antibody negative)
Inclusion criteria for participation in 6-week alcohol abstinence follow-up testing:
-Latinos who are moderate1 alcohol drinkers (1NIAAA definition: female: no more than 3 drinks on any day \& no more than 7 drinks per week; male: no more than 4 drinks on any day and no more than 14 drinks per week).
Steady-State Plasma Glucose \< 180 mg/dL
Exclusion criteria:
Exclusion criteria for healthy (non HCV) Latino volunteers:
-Same as above, including subjects with HCV infection
patients with hepatitis C infection
Behavioral: Moderate alcohol cessation
healthy controls
Behavioral: Moderate alcohol cessation
patients will have moderate alcohol use discontinued for 6 weeks and have before and after alcohol cessation clinical and metabolic assessment and also patients with hepatitis C who have undergo therapy for hepatitis C may have repeat clinical and metabolic assessement
Also known as: Hepatitis C therapy
insulin resistance
steady state plasma glucose level (mg/dL)
Time frame: baseline, 6 weeks and 18 months
Insulin secretion
insulin secretion rate area under the curve (pmol/min)
Time frame: baseline, 6 weeks and 18 months
Plan to share: No
This study is active, not recruiting, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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University of California, San Francisco