An interventional study of Clonidine and Naloxone in Experimental Pain Perception, sponsored by Rambam Health Care Campus. Withdrawn at 1 site in Israel. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-10-04.
Sponsored by Rambam Health Care Campus · Not applicable, Interventional, and Basic science
The role of alpha2 receptor agonist on pain perception and modulation will be examined. In addition whether this is mediated through the opioid system will be examined. Pain perception and modulation will be examined before and after administration of Clonidine or placebo together with Naloxone or saline.
Rambam Health Care Campus is the lead sponsor of 456 studies on the registry; 33 are open to participants now.
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Exclusion Criteria:
Clonidine 0.15 mg and saline 0.15 mg/kg
Drug: Clonidine · Other: saline
Clonidine 0.15 mg and Naloxone 0.15 mg/kg
Drug: Clonidine · Drug: Naloxone
Placebo 0.15 mg+ naloxone 0.15 mg/kg
Drug: Naloxone · Drug: placebo
Placebo 0.15 mg+ saline 0.15 mg/kg
Drug: placebo · Other: saline
Clonidine 0.15 mg
naloxone 0.15 mg/kg
The changes in pain responses after administration of alpha 2 agonist and mu receptor antagonist
The change in pain perception (pain thresholds and pain ratings of suprathresholds stimuli) and in the excitatory and inhibitory pain modulation responses (assessed by the temporal summation and conditioned pain modulation paradigms) will be examined before and after administration of alpha 2 agonist with and without mu receptor antagonist
Time frame: 2 years
This study is withdrawn, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.
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Rambam Health Care Campus